DNA methylation based biomarkers in non-invasive cancer screening.
DNA methylation based biomarkers in non-invasive cancer screening.
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DOI：
10.2174/156652410790963303
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发表时间：
2010-03
影响因子：
2.5
通讯作者：
Gazdar AF
中科院分区：
文献类型：
--
作者：
Shivapurkar N;Gazdar AF
DNA甲基化在基因表达、分化的调节以及癌症和其他疾病的发展中起着关键作用。位于肿瘤抑制基因启动子区域的CpG岛的超甲基化现在被确定为癌症中基因失活的最常见机制。已经显示了使用基于DNA甲基化的生物标志物用于癌症早期检测的可行性。使用DNA甲基化预测治疗结果和患者存活率的潜力也已显示。起源于癌细胞的DNA已经在临床标本中常规检测到（例如，血浆/血清、痰液、尿液等）从癌症患者。甲基化DNA序列在临床标本中的存在和使用它们作为生物标志物的潜力已经得到认可。可用于从癌症患者非侵入性获得的临床标本中的新型基于甲基化的生物标志物提供了显著的实际优势。需要投入更多的资源用于生物标志物研究的这一领域。因此，我们回顾了基于DNA甲基化的癌症生物标志物的最新研究结果，特别关注这些适用于从癌症患者非侵入性获得的临床标本。
DNA methylation plays a critical role in the regulation of gene expression, differentiation and in the development of cancer and other diseases. Hypermethylation of CpG islands located in the promoter regions of tumor suppressor genes is now firmly established as the most frequent mechanism for gene inactivation in cancers. Feasibility of using DNA methylation based biomarkers for early detection of cancer has been shown. Potential of using DNA methylation for prediction of therapeutic outcome and patient survival has also been shown. DNA originated from cancer cells has been routinely detected in clinical specimens (ex. Plasma/serum, sputum, urine etc.) from cancer patients. Presence of methylated DNA sequences in clinical specimens and potential of using them as biomarkers have been recognized. Novel methylation based biomarkers that can be used in clinical specimens, obtained non-invasively from cancer patients, offer significant practical advantages. More resources need to be committed to this area of biomarker research. Thus, we review recent findings on DNA methylation based cancer biomarkers with particular focus on these applicable to the clinical specimens obtained non-invasively from cancer patients.
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影响因子：
11.5
作者：
Belinsky, SA;Klinge, DM;Picchi, MA
通讯作者：
Picchi, MA
影响因子：
5
作者：
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通讯作者：
Dalay, N
影响因子：
9.2
作者：
Daujat, S;Bauer, UM;Kouzarides, T
通讯作者：
Kouzarides, T
影响因子：
9.7
作者：
An, Q;Liu, Y;Cheng, SJ
通讯作者：
Cheng, SJ
DOI：
10.1111/j.1440-1746.1997.tb00513.x
发表时间：
1997-10-01
影响因子：
4.1
作者：
Chen, CJ;Yu, MW;Liaw, YF
通讯作者：
Liaw, YF