CLONING OF A NEW MEMBER OF THE TGF-BETA FAMILY - A PUTATIVE NEW ACTIVIN BETA(C) CHAIN
CLONING OF A NEW MEMBER OF THE TGF-BETA FAMILY - A PUTATIVE NEW ACTIVIN BETA(C) CHAIN
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DOI：
10.1006/bbrc.1995.1086
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发表时间：
1995-01-17
影响因子：
3.1
通讯作者：
POHL, J
中科院分区：
文献类型：
--
作者：
HOTTEN, G;NEIDHARDT, H;POHL, J
通过最初的简并 PCR、随后的人类 cDNA 克隆和核苷酸测序，已经确定了 TGF-β 超家族新成员的完整氨基酸序列。该超家族成员之间的氨基酸同源性比较表明它是激活素/抑制素亚组的新成员。所提出的前体成熟部分显示出与激活素β(B)链有53%的氨基酸同一性，与激活素β(A)链有51%的同一性，而β(A)和β(B)在成员之间显示出64%的同一性。 (C) 1995 学术出版社
The complete amino acid sequence of a new member of the TGF-beta superfamily has been determined through initial degenerate PCR, subsequent cloning and nucleotide sequencing of the human cDNA. Amino acid homology comparison among members of this superfamily suggests it to be a new member of the activin/inhibin subgroup. The proposed mature part of the precursor shows 53 % amino acid identity to the activin beta(B) and 51 % identity to the activin beta(A) chain whereas beta(A) and beta(B) show an identity of 64 % to among members. (C) 1995 Academic Press, Inc.