Effect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus Patients.
Effect of n-3 Polyunsaturated Fatty Acid Supplementation on Metabolic and Inflammatory Biomarkers in Type 2 Diabetes Mellitus Patients.
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DOI：
10.3390/nu9060573
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发表时间：
2017-06-03
期刊：
影响因子：
5.9
通讯作者：
Harbige LS
中科院分区：
文献类型：
--
作者：
Jacobo-Cejudo MG;Valdés-Ramos R;Guadarrama-López AL;Pardo-Morales RV;Martínez-Carrillo BE;Harbige LS
背景：2型糖尿病(T2 DM)伴有慢性低度炎症，脂肪因子分泌失衡，胰岛素抵抗加重。在T2 DM患者中补充n-3PUFA可降低炎症标志物，本研究的目的是观察补充n-3PUFA对T2 DM墨西哥成人脂肪因子、代谢控制和血脂的影响。方法：在一项随机、单盲、安慰剂对照的先导研究中，54名T2 DM患者每天服用520毫克DHA+EPA强化鱼油(FOG)或安慰剂(PG)。基线和24周的人体测量和生化测量包括血糖、胰岛素、糖化血红蛋白(Hb1Ac)、瘦素、脂联素、抵抗素和血脂；n-3多不饱和脂肪酸摄入量以g/d计算。结果：雾化组大鼠腰围和血糖显著降低(p=0.001和p=0.011)。治疗24周后，两组的Hb1Ac(p=0.009和p=0.004)、瘦素(p<；0.000和p<；0.000)、瘦素/脂联素比值(p<；0.000和p<；0.000)均显著下降。两组患者血清抵抗素(FOG p<；0.000和PG p=0.001)、胰岛素(FOG p<；0.000和PG p<；0.000)、胰岛素抵抗指数(HOMA-IR)(FOG p=0.000和PG p<；0.000)均显著升高。FOG组的血脂总体改善，三酰甘油(p=0.002)和动脉粥样硬化指数(p=0.031)显著降低；相比之下，PG组的总胆固醇(p<；0.000)、非高密度脂蛋白胆固醇(p<；0.000)和动脉粥样硬化指数(p=0.017)增加。结论：补充n-3PUFA对两组患者的腰围、血糖、Hb1Ac、瘦素、瘦素/脂联素比值和血脂水平均有一定的改善作用，而对脂联素水平无明显影响，对抵抗素、胰岛素和HOMA-IR均有提高作用。
Background: Type 2 diabetes mellitus (T2DM) is accompanied by chronic low-grade inflammation, with an imbalance in the secretion of adipokines and, worsening insulin resistance. Supplementation with n-3 PUFA in T2DM decreases inflammatory markers, the purpose of the study was to investigate the effect of n-3 PUFA supplementation on adipokines, metabolic control, and lipid profile in T2DM Mexican adults. Methods: In a randomized, single-blind, placebo-controlled pilot study, 54 patients with T2DM received 520 mg of DHA + EPA-enriched fish-oil (FOG) or a placebo (PG) daily. Baseline and 24-week anthropometric and biochemical measurements included glucose, insulin, glycosylated hemoglobin (Hb1Ac), leptin, adiponectin, resistin, and lipid profile; n-3 PUFA intake was calculated in g/day. Results: Waist circumference and blood glucose showed significant reductions in the FOG group (p = 0.001 and p = 0.011, respectively). Hb1Ac (p = 0.009 and p = 0.004), leptin (p < 0.000 and p < 0.000), and leptin/adiponectin ratio (p < 0.000 and p < 0.000) decreased significantly in both groups after 24 weeks (FOG and PG respectively). Serum resistin (FOG p < 0.000 and PG p = 0.001), insulin (FOG p < 0.000 and PG p < 0.000), and HOMA-IR (FOG p = 0.000 and PG p < 0.000) increased significantly in both groups. FOG had an overall improvement in the lipid profile with a significant decrease in triacylgycerols (p = 0.002) and atherogenic index (p = 0.031); in contrast, the PG group had increased total cholesterol (p < 0.000), non-HDL cholesterol (p < 0.000), and atherogenic index (p = 0.017). Conclusions: We found a beneficial effect of n-3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.