Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosus
Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosus
复制标题
DOI：
10.1002/art.20512
复制
发表时间：
2004-10-01
影响因子：
--
通讯作者：
van Buchem, MA
中科院分区：
文献类型：
--
作者：
Bosma, GPT;Steens, SCA;van Buchem, MA
客观的。探讨原发性神经精神系统性红斑狼疮 (NPSLE) 患者的磁化转移成像 (MTI)、弥散加权成像 (DWI)、质子磁共振波谱 (H-MRS) 和 T2 弛豫测量结果之间的关系。方法。研究组由 24 名女性患者（平均年龄 36 岁[范围 23-65]）组成，她们患有多种神经精神症状，根据美国风湿病学会的标准，这些症状被判断为 NPSLE 所致。当前患有活动性疾病的患者被排除在参与之外。采集所有患者的定量MTI、DWI、H-MRS和T2松弛测量数据，并计算相关系数。结果。反映脑实质均匀性降低的 MTI 结果与代表轴突损伤的 H-MRS 结果显着相关。 MTI 结果也与 DWI 结果显着相关，反映了脑实质扩散性的增加。最后，MTI 结果反映大脑均匀性下降与 T2 弛豫时间增加显着相关，与水肿或神经胶质增生相关。 T2 弛豫时间的增加与 DWI 结果显着相关，反映了扩散率的增加。除了H-MRS和MTI结果之间的相关性之外，H-MRS结果和任何其他参数之间没有显着相关性。结论。所选的研究参数代表了人脑的不同生物学特征，并且可以为 NPSLE 的不同病理过程提供信息。有 NPSLE 病史的患者中 MTI、DWI、H-MRS 和 T2 数据之间已证实的关联表明，尽管临床表现存在差异，但 NPSLE 存在一种发病机制和/或常见的神经病理学结果。
Objective. To investigate the relationship between magnetization transfer imaging (MTI), diffusion-weighted imaging (DWI), proton magnetic resonance spectroscopy (H-MRS), and T2 relaxometry findings in patients with primary neuropsychiatric systemic lupus erythematosus (NPSLE).Methods. The study group consisted of 24 female patients (mean age 36 years [range 23-65]) who had had a variety of neuropsychiatric symptoms that were judged to be due to NPSLE according to the criteria of the American College of Rheumatology. Patients with current active disease were excluded from participation. Quantitative MTI, DWI, H-MRS, and T2 relaxometry data were acquired in all patients, and the correlation coefficients were calculated.Results. MTI results reflecting a decrease in homogeneity of cerebral parenchyma correlated significantly with H-MRS results representing axonal damage. MTI results also correlated significantly with DWI results reflecting increased diffusivity in the cerebral parenchyma. Finally, MTI results reflecting decreased cerebral homogeneity correlated significantly with increased T2 relaxation time, associated with either edema or gliosis. Increased T2 relaxation time correlated significantly with DWI results reflecting increased diffusivity. With the exception of the correlation between H-MRS and MTI findings, there was no significant correlation between H-MRS results and any other parameter.Conclusion. The selected study parameters represent different biologic features in the human brain and can be informative with regard to different pathologic processes in NPSLE. The demonstrated associations between MTI, DWI, H-MRS, and T2 data in patients with a history of NPSLE suggest that there is one pathogenesis and/or common neuropathologic outcome in NPSLE despite differences in clinical presentation.