New nomenclature for mpox (monkeypox) and monkeypox virus clades.
New nomenclature for mpox (monkeypox) and monkeypox virus clades.
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DOI：
10.1016/s1473-3099(23)00055-5
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发表时间：
2023-03
影响因子：
56.3
通讯作者：
Lewis, Rosamund F.
中科院分区：
文献类型：
--
作者：
Ulaeto, David;Agafonov, Alexander;Burchfield, Jennifer;Carter, Lisa;Happi, Christian;Jakob, Robert;Krpelanova, Eva;Kuppalli, Krutika;Lefkowitz, Elliot J.;Mauldin, Matthew R.;de Oliveira, Tulio;Onoja, Bernard;Otieno, James;Rambaut, Andrew;Subissi, Lorenzo;Yinka-Ogunleye, Adesola;Lewis, Rosamund F.
导致发现全球疫情的第一份天花报告于2022年5月13日向世卫组织提交。疫情蔓延到110个国家2，并被宣布为国际关注的突发公共卫生事件。世卫组织总干事呼吁会员国确保尊重人权，并解决污名化和歧视问题。截至2023年1月31日，110个国家报告了85549例确诊病例，其中89例死亡。2 Mpox是由猴痘病毒（MPXV）引起的，属正痘病毒，1958年在丹麦的灵长类动物研究机构发现，1970年报道了第一例人类病例。[4]确定了两个病毒分支：刚果盆地（或中非）分支和西非分支。5尽管在非洲爆发疫情期间，污名化成为一个问题，6但2022年的全球疫情重新引发了关于重新命名病毒分支的建议的讨论。7尽管病毒变体的命名是科学家的职责，但迅速达成共识也很重要。2022年8月8日，世卫组织召开了一次特别专家会议，讨论MPXV分支的特征并为它们提出名称。与会者包括正痘病毒学家、进化生物学家和其他科学家，他们来自：（1）美国疾病控制和预防中心和俄罗斯国家病毒学和生物技术研究中心的世卫组织正痘病毒合作中心;（2）世卫组织SARS-CoV-2病毒进化技术咨询小组;（3）世卫组织天花病毒研究咨询委员会;（4）国际病毒分类委员会痘病毒科研究小组;（5）非洲和世界各地的研究和公共卫生机构;（6）公共病毒序列数据库。
The first report of mpox that led to the discovery of the global outbreak was made to WHO on May 13, 2022. The outbreak spread to 110 countries2 and was declared a public health emergency of international concern. The Director-General of WHO called on member states to ensure respect for human rights and to address stigma and discrimination. 3 As of Jan 31, 2023, there were 85 549 confirmed cases of mpox reported by 110 countries, including 89 deaths. 2 Mpox is caused by the species monkeypox virus (MPXV), genus Orthopoxvirus, discovered in 1958 in a primate research facility in Denmark, with the first human case reported in 1970. 4 Two virus clades were identified: the Congo Basin (or central African) clade and the west African clade. 5 Although stigma became a concern during outbreaks in Africa, 6 the 2022 global outbreak reignited discussion with proposals to rename virus clades. 7Although the nomenclature of virus variants is the remit of scientists, reaching consensus quickly was important. On Aug 8, 2022, WHO convened an adhoc expert meeting to discuss characteristics of MPXV clades and propose names for them. Participants included orthopoxvirologists, evolutionary biologists, and other scientists from (1) WHO collaborating centres on orthopoxviruses at the US Centers for Disease Control and Prevention and the Russian State Research Centre of Virology and Biotechnology;(2) the WHO Technical Advisory Group on SARS-CoV-2 Virus Evolution;(3) the WHO Advisory Committee on Variola Virus Research;(4) the Poxviridae study group of the International Committee on the Taxonomy of Viruses;(5) research and public health institutes in Africa and around the world; and (6) public virus-sequence databases.