Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis.
Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis.
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DOI：
10.7150/ijbs.5033
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发表时间：
2012
影响因子：
9.2
通讯作者：
Su DM
中科院分区：
文献类型：
--
作者：
Zhang Z;Burnley P;Coder B;Su DM
“裸”基因（即 FoxN1 基因）的突变会在小鼠（裸鼠）和人类（T 细胞相关的原发性免疫缺陷）中诱导无毛表型和初级胸腺。传统的 FoxN1 基因敲除和转基因小鼠模型已用于研究与皮肤和免疫疾病相关的 FoxN1 基因功能以及癌症模型。看来FoxN1的作用已经被充分理解，裸鼠模型也得到了充分利用。然而，近年来，随着loxP-Cre（ERT）诱导基因敲除/敲入小鼠模型和白喉毒素受体诱导细胞消除系统的发展，FoxN1的完整作用和裸鼠模型在免疫功能研究中的深入应用似乎才刚刚开始。在此，我们总结了近期几项研究 FoxN1 在胸腺中的作用以及利用裸鼠和“第二（条件）裸鼠”模型研究 T 细胞发育和功能的研究进展。我们还提出了问题并建议进一步考虑 FoxN1 功能并利用该小鼠模型进行免疫功能研究。
Mutation in the “nude” gene, i.e. the FoxN1 gene, induces a hairless phenotype and a rudimentary thymus gland in mice (nude mouse) and humans (T-cell related primary immunodeficiency). Conventional FoxN1 gene knockout and transgenic mouse models have been generated for studies of FoxN1 gene function related to skin and immune diseases, and for cancer models. It appeared that FoxN1's role was fully understood and the nude mouse model was fully utilized. However, in recent years, with the development of inducible gene knockout/knockin mouse models with the loxP-Cre(ERT) and diphtheria toxin receptor-induced cell abolished systems, it appears that the complete repertoire of FoxN1's roles and deep-going usage of nude mouse model in immune function studies have just begun. Here we summarize the research progress made by several recent works studying the role of FoxN1 in the thymus and utilizing nude and “second (conditional) nude” mouse models for studies of T-cell development and function. We also raise questions and propose further consideration of FoxN1 functions and utilizing this mouse model for immune function studies.
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DOI：
10.1006/bbrc.1997.7124
发表时间：
1997-08-28
影响因子：
3.1
作者：
Feil, R;Wagner, J;Chambon, P
通讯作者：
Chambon, P
影响因子：
48
作者：
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通讯作者：
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
1.9
作者：
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通讯作者：
Pignata, C
DOI：
10.1073/pnas.93.20.10887
发表时间：
1996-10-01
影响因子：
11.1
作者：
Feil, R;Brocard, J;Chambon, P
通讯作者：
Chambon, P