Electrospun bioresorbable heart valve scaffold for tissue engineering
Electrospun bioresorbable heart valve scaffold for tissue engineering
复制标题
DOI：
10.1177/039139880803100110
复制
发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
De Angelis, G.
中科院分区：
文献类型：
--
作者：
Del Gaudio, C.;Grigioni, M.;De Angelis, G.
目前市售的机械或生物人工心脏瓣膜被认为是患有退行性病变的天然心脏瓣膜的有效替代品。由于功能障碍或术后并发症，这些器械需要严格随访。这些医疗器械的潜在缺点是钙化、瓣尖撕裂、血栓栓塞和溶血。在这种情况下，组织工程的方法提供了一个有前途的替代scillation.In本文中，三叶聚（ε-己内酯）（PCL）的心脏瓣膜支架原型已通过静电纺丝技术，使用定制的旋转目标。选择工艺参数以获得合适的显微组织和机械性能。电纺心脏瓣膜原型通过脉冲复制器进行功能表征，以评价对施加的测试条件的机械/液压响应。瓣叶在射血期同步打开，瓣叶的正确对合防止了舒张期的高渗漏量，这一初步研究为设计新型组织工程生物可吸收心脏瓣膜的方法提供了成功的前景。
Currently marketed mechanical or biological prosthetic heart valves are regarded as valid substitutes for native heart valves suffering from degenerative pathologies. These devices require strict follow-up due to dysfunctions or post-surgical complications. Potential drawbacks of these medical devices are calcification, tearing of the cusps, thromboembolism and hemolysis. In this context, a tissue engineering approach offers a promising alternative scenario.In this paper, a trileaflet poly(epsilon-caprolactone) (PCL) heart valve scaffold prototype has been manufactured by electrospinning technique using a custom-made rotating target. Process parameters were selected in order to achieve suitable microstructure and mechanical performance. The electrospun heart valve prototype was functionally characterized by means of a pulse duplicator in order to evaluate the mechanical/hydraulic response to the imposed testing conditions. Leaflets synchronously opened in the ejection phase and the proper apposition of the leaflets prevented high leakage volumes in the diastolic phase.This preliminary study suggests a successful perspective for the proposed approach in designing a novel tissue engineered bioresorbable heart valve.