Responses to oral Δ9-tetrahydrocannabinol in frequent and infrequent marijuana users
Responses to oral Δ9-tetrahydrocannabinol in frequent and infrequent marijuana users
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DOI：
10.1016/s0091-3057(98)00264-0
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发表时间：
1999-05-01
影响因子：
3.6
通讯作者：
de Wit, H
中科院分区：
文献类型：
--
作者：
Kirk, JM;de Wit, H
众所周知，一个人的用药史会影响一些临床使用的精神活性药物如巴比妥酸盐、地西泮和吗啡后的主观反应的质量。然而，尚不清楚药物使用史是否也会影响对Delta(9)-THC等治疗性大麻素的反应。Tnt目前的实验比较了两组志愿者口服Delta(9)-THC的主观和行为影响：频繁使用者（FREQ; ii = 11），报告使用大麻至少100次，不频繁使用者（INF: n = 10）报告使用大麻10次或更少。受试者参加了三个疗程，在此期间他们接受Delta(9)-THC（7.5和15毫克）和安慰剂。他们在给药后5小时内完成主观效果问卷。在FREQ组中，相对于安慰剂，较低剂量（7.5 mg）增加了“感觉药物”的评分，而在INF组中没有效果。相比之下，在较高剂量（15mg）下，FREQ组的“感觉药物”评分低于INF组，提示耐受性。此外，在更高剂量的Delta(9)-THC后，INF组的镇静作用比FREQ组更强，再次表明对Delta(9)-THC的镇静作用有耐受性。这些发现表明，大麻使用历史可能会影响口服Delta(9)-THC的主观效果，但药物使用历史的影响取决于给药剂量。这些发现可能会对Delta(9)-THC和其他大麻素的临床使用产生影响。(C) 1999 Elsevier Science Inc.；
It is known that an individual's drug use history affects the quality of subjective effects experienced following administration of several clinically used psychoactive drugs such as barbiturates, diazepam, and morphine. However, it is not known whether drug use history also affects responses to therapeutic cannabinoids such as Delta(9)-THC. Tnt current experiment compared the subjective and behavioral effects of oral Delta(9)-THC in two groups of volunteers: frequent users (FREQ; ii = 11), who reported using marijuana at least 100 times, and infrequent users (INF: n = 10) who reported using marijuana 10 or fewer times. Subjects participated in three sessions during which they received Delta(9)-THC (7.5 and 15 mg) and placebo. They completed subjective effects questionnaires for 5 h following administration. In the FREQ group, the lower dose (7.5 mg) increased ratings of "feel drug," relative to placebo, whereas it had no effect in the INF group. In contrast, at the higher dose (15 mg), ratings of "feel drug" were lower in the FREQ group than in the INF group, suggestive of tolerance. In addition, the INF group reported greater sedative effects than the FREQ group following the higher dose of Delta(9)-THC, again suggesting tolerance to Delta(9)-THC's sedative effects. These findings demonstrate that marijuana use history may affect the subjective effects of oral Delta(9)-THC, but that the influence of drug use history depends on the dose of drug administered. These findings may have implications for the clinical use of Delta(9)-THC and other cannabinoids. (C) 1999 Elsevier Science Inc.