Regulation of Drosophila courtship behavior by the Tlx/tailless-like nuclear receptor, dissatisfaction
Regulation of Drosophila courtship behavior by the Tlx/tailless-like nuclear receptor, dissatisfaction
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DOI：
10.1016/j.cub.2022.02.031
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发表时间：
2022-02
期刊：
影响因子：
9.2
通讯作者：
Julia C. Duckhorn;J. Cande;Mary C. Metkus;Hyeop Song;Sofia Altamirano;D. Stern;Troy R. Shirangi
中科院分区：
文献类型：
--
作者：
Julia C. Duckhorn;J. Cande;Mary C. Metkus;Hyeop Song;Sofia Altamirano;D. Stern;Troy R. Shirangi
果蝇的性二态求偶行为是由性别分化基因双性(Dsx)和无果性(Fru)的活性发展而来的，这些基因与其他调节因素一起发挥作用，而这些调节因素几乎没有受到关注。不满意(Dsf)基因编码一种与脊椎动物Tlx和果蝇无尾同源的孤儿核受体，这对雌性和雄性特有的性行为的几个方面的发展至关重要。在这里，我们报告了dsf在中枢神经系统中的表达模式，并表明共同表达dsf和dsx的性二态腹部中间神经元的活动是处女雌性阴道板打开、交配雌性产卵器排出和雄性求偶期间腹部卷曲的必要条件和充分条件。我们发现，在雌性和雄性中，dsfactivity导致不同的神经解剖学结果，根据dsx表达的性别状态，分别促进和抑制女性的发育和这些神经元的功能。我们假设dsfx和dsxx相互作用，以确定在腹部二态行为的神经回路中的性别差异。
Sexually dimorphic courtship behaviors inDrosophila melanogasterdevelop from the activity of the sexual differentiation genes,doublesex(dsx) andfruitless(fru), functioning with other regulatory factors that have received little attention. Thedissatisfaction(dsf) gene encodes an orphan nuclear receptor homologous to vertebrateTlxandDrosophila taillessthat is critical for the development of several aspects of female- and male-specific sexual behaviors. Here, we report the pattern ofdsfexpression in the central nervous system and show that the activity of sexually dimorphic abdominal interneurons that co-expressdsfanddsxis necessary and sufficient for vaginal plate opening in virgin females, ovipositor extrusion in mated females, and abdominal curling in males during courtship. We find thatdsfactivity results in different neuroanatomical outcomes in females and males, promoting and suppressing, respectively, female development and function of these neurons depending upon the sexual state ofdsxexpression. We posit thatdsfanddsxinteract to specify sex differences in the neural circuitry for dimorphic abdominal behaviors.