Social isolation impairs the persistence of social recognition memory by disturbing the glutamatergic tonus and the olfactory bulb-dorsal hippocampus coupling
Social isolation impairs the persistence of social recognition memory by disturbing the glutamatergic tonus and the olfactory bulb-dorsal hippocampus coupling
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DOI：
10.1038/s41598-018-36871-6
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发表时间：
2019-01-24
影响因子：
4.6
通讯作者：
Pereira, Grace S.
中科院分区：
文献类型：
--
作者：
Almeida-Santos, Ana F.;Carvalho, Vinicius R.;Pereira, Grace S.
缺乏同伴可能会危及社会动物的心理健康。在这里，我们测试的假设，社会隔离损害社会识别记忆，通过改变兴奋性和对话之间的嗅球（OB）和背海马（dHIP）。成年雄性Swiss小鼠保持分组（GH）或隔离（SI）7天。社会记忆（LTM）采用社会认知测验进行评估。SI可增加OB的谷氨酸释放，而减少dHIP的谷氨酸释放。阻断AMPA和NMDA受体进入OB或激活AMPA进入dHIP挽救了SI小鼠的LTM，表明谷氨酸水平和LTM损伤之间存在因果关系。此外，在记忆检索期间，SI小鼠中OB和dHIP之间的相位-振幅耦合降低。我们的研究结果表明，SI损害了OB和HIP之间的神经递质信号和正常通信，损害了社会记忆的持久性。
The absence of companion may jeopardize mental health in social animals. Here, we tested the hypothesis that social isolation impairs social recognition memory by altering the excitability and the dialog between the olfactory bulb (OB) and the dorsal hippocampus (dHIP). Adult male Swiss mice were kept grouped (GH) or isolated (SI) for 7 days. Social memory (LTM) was evaluated using social recognition test. SI increased glutamate release in the OB, while decreased in the dHIP. Blocking AMPA and NMDA receptors into the OB or activating AMPA into the dHIP rescued LTM in SI mice, suggesting a cause-effect relationship between glutamate levels and LTM impairment. Additionally, during memory retrieval, phase-amplitude coupling between OB and dHIP decreased in SI mice. Our results indicate that SI impaired the glutamatergic signaling and the normal communication between OB and HIP, compromising the persistence of social memory.