Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview.
Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview.
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DOI：
10.1097/ee9.0000000000000166
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发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Slama R
中科院分区：
文献类型：
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作者：
Vrijheid M;Basagaña X;Gonzalez JR;Jaddoe VWV;Jensen G;Keun HC;McEachan RRC;Porcel J;Siroux V;Swertz MA;Thomsen C;Aasvang GM;Andrušaitytė S;Angeli K;Avraam D;Ballester F;Burton P;Bustamante M;Casas M;Chatzi L;Chevrier C;Cingotti N;Conti D;Crépet A;Dadvand P;Duijts L;van Enckevort E;Esplugues A;Fossati S;Garlantezec R;Gómez Roig MD;Grazuleviciene R;Gützkow KB;Guxens M;Haakma S;Hessel EVS;Hoyles L;Hyde E;Klanova J;van Klaveren JD;Kortenkamp A;Le Brusquet L;Leenen I;Lertxundi A;Lertxundi N;Lionis C;Llop S;Lopez-Espinosa MJ;Lyon-Caen S;Maitre L;Mason D;Mathy S;Mazarico E;Nawrot T;Nieuwenhuijsen M;Ortiz R;Pedersen M;Perelló J;Pérez-Cruz M;Philippat C;Piler P;Pizzi C;Quentin J;Richiardi L;Rodriguez A;Roumeliotaki T;Sabin Capote JM;Santiago L;Santos S;Siskos AP;Strandberg-Larsen K;Stratakis N;Sunyer J;Tenenhaus A;Vafeiadi M;Wilson RC;Wright J;Yang T;Slama R
生命早期阶段易受环境危害的影响，并为终身疾病预防提供了重要的机会。这使得早期生活成为麻烦研究的相关起点。人类早期生命过程暴露组研究和翻译的先进工具（ATHNOW）项目旨在开发一个工具箱和一个欧洲范围的暴露组队列，用于系统地量化各种社区和个人水平的环境风险因素对心理，心脏代谢和呼吸健康结果以及相关生物途径的影响，纵向从早孕到青春期。暴露组工具和数据开发包括以下内容：（1）一个可查找、可访问、可互操作、可重复使用（FAIR）的数据基础设施，用于早期生命暴露组队列数据，包括11个欧洲国家的16个预期出生队列;（2）有针对性和无针对性的方法来测量广泛的环境暴露（城市，化学，物理，行为，社会）;（3）先进的统计和毒理学策略来分析复杂的多维麻烦数据;（4）评估疾病与早期器官发育、健康轨迹和生物学之间的关联。（宏基因组学、代谢组学、表观遗传学、衰老和压力）途径;（5）改善与当地社区共同产生的早期生活城市和化学疾病组的干预策略;（6）儿童健康影响和与疾病组相关的相关成本。数据、工具和结果将汇集在一个可公开访问的工具箱中，这将为研究人员、政策制定者和其他利益攸关方提供项目持续时间以外的巨大机会。ATHENG的研究结果将有助于更好地了解和预防从生命历程的最早阶段开始的环境暴露及其混合物对健康的损害。
Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing Tools for Human Early Lifecourse Exposome Research and Translation (ATHLETE) project aims to develop a toolbox of exposome tools and a Europe-wide exposome cohort that will be used to systematically quantify the effects of a wide range of community- and individual-level environmental risk factors on mental, cardiometabolic, and respiratory health outcomes and associated biological pathways, longitudinally from early pregnancy through to adolescence. Exposome tool and data development include as follows: (1) a findable, accessible, interoperable, reusable (FAIR) data infrastructure for early life exposome cohort data, including 16 prospective birth cohorts in 11 European countries; (2) targeted and nontargeted approaches to measure a wide range of environmental exposures (urban, chemical, physical, behavioral, social); (3) advanced statistical and toxicological strategies to analyze complex multidimensional exposome data; (4) estimation of associations between the exposome and early organ development, health trajectories, and biological (metagenomic, metabolomic, epigenetic, aging, and stress) pathways; (5) intervention strategies to improve early life urban and chemical exposomes, co-produced with local communities; and (6) child health impacts and associated costs related to the exposome. Data, tools, and results will be assembled in an openly accessible toolbox, which will provide great opportunities for researchers, policymakers, and other stakeholders, beyond the duration of the project. ATHLETE’s results will help to better understand and prevent health damage from environmental exposures and their mixtures from the earliest parts of the life course onward.