Progress in the development of the DexAide right ventricular assist device.
Progress in the development of the DexAide right ventricular assist device.
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DexAide 右心室辅助装置的开发进展。
DOI：
10.1097/01.mat.0000240700.03478.d0
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Golding,Leonard
中科院分区：
文献类型：
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作者：
Fukamachi,Kiyotaka;Ootaki,Yoshio;Horvath,DavidJ;Massiello,AlexL;Kamohara,Keiji;Akiyama,Masatoshi;Cingoz,Faruk;Ootaki,Chiyo;KopcakJr,MichaelW;Dessoffy,Raymond;Liu,Jenny;Chen,Ji-Feng;Zhou,Qun;Benefit,Stephen;Golding,Leonard
DexAide右心室辅助装置（RVAD）是由CorAide左心室辅助装置改良而来的植入式离心泵。如先前发表的，DexAide RVAD的体外性能测试符合设计标准，并且在2，000 rpm下实现了4 l/min和20 mm Hg压力升高的标称操作条件，功耗为1.9 W。14头小牛的体内研究证明了可接受的血流动力学特征。小腿流入套管设计仍在不断发展，以最大限度地减少在大多数实验中观察到的套管上的沉积物。在5具尸体和2名患者中进行了拟合研究，以重新配置套管用于人体。独立RVAD系统的外部电子设备的设计和开发已经完成，正在进行验证测试，为临床前测试做准备。双心室辅助系统的外部电子设计工作正在进行中。
The DexAide right ventricular assist device (RVAD) is an implantable centrifugal pump modified from the CorAide left ventricular assist device. As previously published, in vitro performance testing of the DexAide RVAD has met design criteria, and the nominal operating condition of 4 l/min and 20 mm Hg pressure rise was achieved at 2,000 rpm, with a power consumption of 1.9 watts. In vivo studies in 14 calves have demonstrated acceptable hemodynamic characteristics. The calf inflow cannula design is still evolving to minimize depositions on the cannula observed in most experiments. Fitting studies were performed in 5 cadavers and 2 patients to reconfigure the cannulae for use in humans. The design and development of external electronics have been completed for the stand-alone RVAD system, and verification tests are under way in preparation for preclinical tests. Work on the external electronics design for the biventricular assist system is ongoing.