Natural killer T cells contribute to the control of acute retroviral infection.
Natural killer T cells contribute to the control of acute retroviral infection.
复制标题
天然杀手T细胞有助于控制急性逆转录病毒感染。
DOI：
10.1186/s12977-017-0327-8
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发表时间：
2017-01-26
期刊：
影响因子：
3.3
通讯作者：
Dittmer U
中科院分区：
文献类型：
--
作者：
Littwitz-Salomon E;Schimmer S;Dittmer U
自然杀伤T细胞（NKT细胞）在抵抗病毒感染的免疫中起重要作用。它们产生细胞因子或具有直接的细胞溶解作用，可以限制病毒复制。然而，NKT细胞在逆转录病毒免疫中的确切功能尚未完全阐明。因此，我们分析了NKT细胞在Friend逆转录病毒（FV）感染的小鼠中的抗逆转录病毒功能。FV感染后，NKT细胞数量无明显变化，但其活化程度及效应功能均有所增强，而促炎细胞因子的释放无明显变化，活化的NKT细胞的细胞毒活性明显增强。用α-半乳糖神经酰胺刺激不仅显著增加了总NKT细胞数量和活化，而且还增加了NKT细胞的抗逆转录病毒能力。我们证明了在急性逆转录病毒感染期间NKT细胞的强激活和有效的细胞溶解功能。使用α-半乳糖神经酰胺进行治疗可以进一步减少NKT细胞的早期逆转录病毒复制，这可用于未来针对病毒感染的治疗。本文的在线版本（doi：10.1186/s12977-017-0327-8）包含补充材料，可供授权用户使用。
Natural killer T cells (NKT cells) play an important role in the immunity against viral infections. They produce cytokines or have direct cytolytic effects that can restrict virus replication. However, the exact function of NKT cells in retroviral immunity is not fully elucidated. Therefore, we analyzed the antiretroviral functions of NKT cells in mice infected with the Friend retrovirus (FV). After FV infection numbers of NKT cells remained unchanged but activation as well as improved effector functions of NKT cells were found. While the release of pro-inflammatory cytokines was not changed after infection, activated NKT cells revealed an elevated cytotoxic potential. Stimulation with α-Galactosylceramide significantly increased not only total NKT cell numbers and activation but also the anti-retroviral capacity of NKT cells. We demonstrate a strong activation and a potent cytolytic function of NKT cells during acute retroviral infection. Therapeutic treatment with α-Galactosylceramide could further improve the reduction of early retroviral replication by NKT cells, which could be utilized for future treatment against viral infections. The online version of this article (doi:10.1186/s12977-017-0327-8) contains supplementary material, which is available to authorized users.