[Neural control of pancreatic secretion].
[Neural control of pancreatic secretion].
复制标题
胰腺分泌的神经控制。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
P. Layer
中科院分区：
文献类型：
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作者：
M. Singer;W. Niebel;P. Layer
在人类和许多实验室动物中，蛋白质和脂肪消化产物是胰腺酶分泌的有效肠道刺激物。神经和激素途径介导酶对这些肠道兴奋剂的反应。肠胰，胆碱能，迷走-迷走反射可能是最重要的介质的酶的低负荷的氨基酸，脂肪酸和盐酸的反应，激素，如胆囊收缩素，似乎是主要的介质的高负荷的氨基酸，脂肪酸和盐酸的反应。胃酸是餐后胰腺碳酸氢盐分泌的主要调节剂。盐酸释放的促胰液素可能是餐后胰腺碳酸氢盐分泌的最重要的生理激素介质;其作用通过外源性（迷走神经）和内源性（胰腺内）胆碱能神经以及其他激素（如胆囊收缩素）的释放而增强。在生理条件下，可能是神经和激素机制的相互作用调节胰腺对肠道刺激剂的反应。然而，神经和激素的这种相互作用是非常未知的。
In humans and many laboratory animals, protein and fat digestion products are potent intestinal stimulants of pancreatic enzyme secretion. Both neural and hormonal pathways mediate the enzyme response to these intestinal stimulants. Enteropancreatic, cholinergic, vago-vagal reflexes are probably the most important mediators of the enzyme response to low loads of amino acids, fatty acids and HCl; hormones, such as cholecystokinin, seem to be the major mediators of the response to high loads of amino acids, fatty acids and HCl. Gastric acid is the major regulator of postprandial pancreatic bicarbonate secretion. Secretin released by HCl is probably the most important physiological hormonal mediator of postprandial pancreatic bicarbonate secretion; its effect being potentiated by extrinsic (vagal) and intrinsic (intrapancreatic) cholinergic nerves and release of other hormones, such as cholecystokinin. Under physiological conditions it is probably the interplay of neural and hormonal mechanisms which regulates the pancreatic response to intestinal stimulants. However, this interaction of nerves and hormones is greatly unknown.