Oxidative cell membrane alteration. Evidence for surfactant-mediated sealing.
Oxidative cell membrane alteration. Evidence for surfactant-mediated sealing.
复制标题
氧化细胞膜改变。
DOI：
10.1111/j.1749-6632.1999.tb07962.x
复制
发表时间：
1999
影响因子：
5.2
通讯作者：
Lee,RC
中科院分区：
文献类型：
--
作者：
Terry,MA;Hannig,J;Carrillo,CS;Beckett,MA;Weichselbaum,RR;Lee,RC
暴露于非常强的电离辐射会产生急性组织后遗症，包括炎症、疼痛和肿胀，通常会导致组织纤维化和/或坏死。急性组织坏死发生在数小时内，当足够快的损伤膜脂质和蛋白质导致改变膜结构，破坏细胞生存所必需的重要电化学扩散屏障。1，2这种损伤机制被认为是致死性辐射有丝分裂后细胞（如神经元）间期死亡的基础，但它也与淋巴细胞的快速细胞死亡和毛细血管上皮功能障碍引起的急性血管变化有关。3，4目前尚不清楚密封辐射渗透的细胞膜是否会延长致死辐射细胞的存活时间或可能导致受损核酸的修复。本研究的目的是开始解决第一个问题。
Exposure to very intense ionizing irradiation produces acute tissue sequelae including inflammation, pain, and swelling that often results in tissue fibrosis and/or necrosis. Acute tissue necrosis occurs in hours when sufficiently rapid damage to membrane lipids and proteins leads to altered membrane structure, disrupting the vital electrochemical diffusion barrier necessary for cell survival. 1,2 This damage mechanism is thought to underlie the interphase death of lethally irradiated postmitotic cells such as neurons, but it has also been implicated in the rapid cell death of lymphocytes and acute vascular changes due to capillary epithelium dysfunction. 3,4 It is not known whether sealing of radiation‐permeabilized cell membranes will prolong survival of lethally irradiated cells or perhaps lead to repair of damaged nucleic acids. The purpose of this study is to begin to address the first question.