Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.
Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.
复制标题
炎症介质及其与睡眠的相互作用：与慢性疲劳综合征和相关病症的相关性。
DOI：
10.1111/j.1749-6632.2001.tb05825.x
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发表时间：
2001
影响因子：
5.2
通讯作者：
Pollmächer,T
中科院分区：
文献类型：
--
作者：
Mullington,JM;Hinze-Selch,D;Pollmächer,T
Abstract:In humans, activation of the primary host defense system leads to increased or decreased NREM sleep quality, depending on the degree of early immune activation. Modest elevations of certain inflammatory cytokines are found during experimental sleep loss in humans and, in addition, relatively small elevations of cytokines are seen following commencement of pharmacological treatments with clozapine, a CNS active antipsychotic agent, known to have immunomodulatory properties. Cytokines such as TNF‐α, its soluble receptors, and IL‐6, present in the periphery and the CNS, comprise a link between peripheral immune stimulation and CNS‐mediated behaviors and experiences such as sleep, sleepiness, and fatigue. The debilitating fatigue experienced in chronic fatigue syndrome and related diseases may also be related to altered cytokine profiles.
