Recruitment of tendon crimp with applied tensile strain
Recruitment of tendon crimp with applied tensile strain
复制标题
DOI：
10.1115/1.1427698
复制
发表时间：
2002-02-01
影响因子：
1.7
通讯作者：
Barton, JK
中科院分区：
文献类型：
--
作者：
Hansen, KA;Weiss, JA;Barton, JK
韧带和肌腱的拉伸应力-应变行为始于脚趾区域，据信这是由卷曲胶原原纤维的拉直引起的。原位机械功能主要局限于该脚趾区域，并且认为卷曲形态的变化与病理状况相关。一种相对较新的成像技术，光学相干断层扫描（OCT），提供了一种相对便宜的方法，用于组织超微结构的非破坏性研究，分辨率约为15 μ m，并有可能用于临床环境。这项工作的目的是评估OCT用于可视化卷曲期的效用，并使用OCT来确定卷曲周期如何作为大鼠尾肌腱束中施加的拉伸应变的函数而变化。从大鼠尾肌腱的筋膜进行0.5%的应变增量高达5%，并在每个增量使用OCT成像。OCT图像和光学显微镜图像之间的比较交叉偏振透镜之间显示的卷曲模式的功能指示之间的视觉对应关系。在达到3%的轴向应变之前，卷曲图案总是完全消失。平均卷曲期随应变的增加而增加，但在单卷曲期内发生伸长和缩短。
The tensile stress-strain behavior of ligaments and tendons begins with a toe region that is believed to result from the straightening of crimped collagen fibrils. The in situ mechanical function is mostly confined to this toe region and changes in crimp morphology are believed to be associated with pathological conditions. A relatively new imaging technique, optical coherence tomography (OCT), provides a comparatively inexpensive method for nondestructive investigation of tissue ultrastructure with resolution on the order of 15 mum and the potential for use in a clinical setting, The objectives of this work were to assess the utility of OCT for visualizing crimp period, and to use OCT to determine how crimp period changed as a function of applied tensile strain in rat tail tendon fascicles. Fascicles from rat tail tendons were subjected to 0.5 percent strain increments up to 5 percent and imaged at each increment using OCT. A comparison between OCT images and optical microscopy images taken between crossed polarizing lenses showed a visual correspondence between features indicative of crimp pattern. Crimp pattern always disappeared completely before 3 percent axial strain was reached. Average crimp period increased as strain increased, but both elongation and shortening occurred within single crimp periods during the application of increasing strain to the fascicle.