Prevalence and serodiversity of the pandemic clone among the clinical strains of Vibrio parahaemolyticus isolated in southern Thailand
Prevalence and serodiversity of the pandemic clone among the clinical strains of Vibrio parahaemolyticus isolated in southern Thailand
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DOI：
10.1017/s0950268803008458
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发表时间：
2003-06-01
影响因子：
4.2
通讯作者：
Nishibuchi, M
中科院分区：
文献类型：
--
作者：
Laohaprertthisan, V;Chowdhury, A;Nishibuchi, M
1999年，我们在泰国南部的两家医院收集了腹泻样本，以检查副溶血性弧菌大流行性克隆感染是否普遍。从317份标本中分离出副溶血性弧菌。76%的分离菌株具有大流行性克隆特异性特征（tdh（+）、trh（-）和可通过GS-PCR检测到的独特toxRS序列）和相关特征（f237噬菌体的ORF 8序列）。这些菌株属于三个大流行伺服型，其中O3：K6菌株占优势，另外三个血清型（O 1：K25，O 1：K41和O 4：K12）。我们还发现01：K25和01：K41菌株与流行性克隆的具体特征，从国际旅行者谁离开泰国和其他三个亚洲国家之间的1998年和1999年分离的菌株，验证这些菌株的流行潜力。结果表明，在泰国南部的流行性克隆感染的患病率，并建议在这一地区出现各种血清变异及其在国际传播的影响。
We collected diarrhoea specimens in two hospitals in southern Thailand in 1999 to examine whether infection by the Vibrio parahaemolyticus pandemic clone is prevalent. V. parahaemolyticus was isolated from 317 specimens. Seventy-six per cent of the isolated strains had the pandemic clone-specific characteristics (tdh(+), trh(-), and an unique toxRS sequence detectable by GS-PCR) and an associated characteristic (the ORF8 sequence of f237 phage). These strains belonged to the three pandemic servovars with the O3: K6 strains being dominant and three other serovars (O1 : K25, O1: K41 and O4: K12). We also found 01:K25 and 01:K41 strains with the pandemic clone-specific characteristics among the strains isolated from the international travellers who left Thailand and three other Asian countries between 1998 and 1999, verifying pandemic potential of these strains. The results demonstrate prevalence of infection by the pandemic clone in southern Thailand and suggest emergence of various serovariants in this area and their implication in international spread.