Two new ambuic acid analogs from Pestalotiopsis sp cr013
Two new ambuic acid analogs from Pestalotiopsis sp cr013
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DOI：
10.1016/j.phytol.2014.10.002
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发表时间：
2014-12-01
影响因子：
1.7
通讯作者：
Zhao, Pei-Ji
中科院分区：
文献类型：
--
作者：
Xie, Jin;Li, Jing;Zhao, Pei-Ji
拟盘多毛孢是一个高度多产的属，具有多种多样的次生代谢物。从克罗纳artium ribicola的芽孢中分离得到拟盘多毛孢spcr013，并对其生长环境进行了植物化学研究。为了解拟盘多毛菌cr013的次生代谢产物，从该菌的固体发酵产物中分离到两个新化合物1和2。通过广泛的光谱分析，包括一维和二维核磁共振，以及HR-ESI-MS实验，发现了两个新的结构。化合物1对5种癌细胞表现出较弱的细胞毒活性，IC50值分别为18.99 μ M （HL-60）、17.68 μ M （SMMC-7721）、18.28 μ M （A-549）、21.67 μ M （MCF-7）和12.27 μ M （SW480）。(C) 2014年欧洲植物化学学会。Elsevier B.V.版权所有。
Pestalotiopsis is a highly prolific genus with a plethora of diverse secondary metabolites. Pestalotiopsis sp. cr013 was isolated from aeciospores of Cronartium ribicola and subjected to phytochemical investigation based on its special environment. To understand the secondary metabolites of strain Pestalotiopsis sp. cr013, two new compounds 1 and 2 were isolated from solid fermentation products of the fungus. Two new structures were elucidated by extensive spectroscopic analyses, including 1D- and 2D-NMR, and HR-ESI-MS experiments. Compound 1 exhibited weak cytotoxicity activity against five cancer cell lines, with IC50 values of 18.99 mu M (HL-60), 17.68 mu M (SMMC-7721), 18.28 mu M (A-549), 21.67 mu M (MCF-7) and 12.27 mu M (SW480). (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.