Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.
Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis.
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DOI：
10.1098/rsob.150093
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发表时间：
2015-09
期刊：
影响因子：
5.8
通讯作者：
Bakal C
中科院分区：
文献类型：
--
作者：
Sanchez-Alvarez M;Zhang Q;Finger F;Wakelam MJ;Bakal C
我们发现，在后生动物细胞周期中，磷脂合成代谢并不是均匀发生的。脂肪前体的最佳动员、特定磷脂物种的合成和内质网(ER)的动态平衡都需要过渡到S阶段。在刺激细胞生长时，观察到的全细胞磷脂组成和总内质网脂肪含量的平均变化可以用种群的细胞周期分布来解释。Torc1通过减缓S/G2的进展促进磷脂合成代谢。脂质生物发生的细胞周期阶段特异性依赖于P53。我们认为，将脂质代谢与细胞周期进程相结合是细胞进化以协调细胞和细胞器生长的一种方式。
We show that phospholipid anabolism does not occur uniformly during the metazoan cell cycle. Transition to S-phase is required for optimal mobilization of lipid precursors, synthesis of specific phospholipid species and endoplasmic reticulum (ER) homeostasis. Average changes observed in whole-cell phospholipid composition, and total ER lipid content, upon stimulation of cell growth can be explained by the cell cycle distribution of the population. TORC1 promotes phospholipid anabolism by slowing S/G2 progression. The cell cycle stage-specific nature of lipid biogenesis is dependent on p53. We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth.