Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis.
Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis.
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DOI：
10.1002/ana.24117
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发表时间：
2014-03
影响因子：
11.2
通讯作者：
Dalmau, Josep
中科院分区：
文献类型：
--
作者：
Titulaer, Maarten J.;Hoeftberger, Romana;Iizuka, Takahiro;Leypoldt, Frank;McCracken, Lindsey;Cellucci, Tania;Benson, Leslie A.;Shu, Huidy;Irioka, Takashi;Hirano, Makito;Singh, Gagandeep;Cobo Calvo, Alvaro;Kaida, Kenichi;Morales, Pamela S.;Wirtz, Paul W.;Yamamoto, Tomotaka;Reindl, Markus;Rosenfeld, Myrna R.;Graus, Francesc;Saiz, Albert;Dalmau, Josep
To report the clinical, radiological, and immunological association of demyelinating disorders with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. Clinical and radiological analysis of a cohort of 691 patients with anti-NMDAR encephalitis. Determination of antibodies to NMDAR, aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) was performed using brain immunohistochemistry and cell-based assays. Twenty-three of 691 patients with anti-NMDAR encephalitis had prominent MRI and/or clinical features of demyelination. Group 1 included 12 patients in whom anti-NMDAR encephalitis was preceded or followed by independent episodes of NMO-spectrum disorder (5 cases, 4 anti-AQP4-positive), or brainstem or multifocal demyelinating syndromes (7 cases, all anti-MOG-positive). Group 2 included 11 patients in whom anti-NMDAR encephalitis occurred simultaneously with MRI and symptoms compatible with demyelination (5 AQ4-positive, 2 MOG-positive). Group 3 (136 controls) included 50 randomly selected patients with typical anti-NMDAR encephalitis, 56 with NMO, and 30 with multiple sclerosis: NMDAR-antibodies were detected only in the 50 anti-NMDAR patients, MOG-antibodies in 3/50 anti-NMDAR and 1/56 NMO patients, and AQP4-antibodies in 48/56 NMO and 1/50 anti-NMDAR patients (p<0.0001 for all comparisons with Groups 1 and 2). Most patients improved with immunotherapy, but compared with anti-NMDAR encephalitis the demyelinating episodes required more intensive therapy and resulted in more residual deficits. Only 1/23 NMDAR patients with signs of demyelination had ovarian teratoma compared with 18/50 anti-NMDAR controls (p=0.011) Patients with anti-NMDAR encephalitis may develop concurrent or separate episodes of demyelinating disorders, and conversely patients with NMO or demyelinating disorders with atypical symptoms (e.g., dyskinesias, psychosis) may have anti-NMDAR encephalitis.
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影响因子：
9.9
作者：
Wingerchuk, D. M.;Lennon, V. A.;Weinshenker, B. G.
通讯作者：
Weinshenker, B. G.
影响因子：
9.9
作者：
Kitley, Joanna;Woodhall, Mark;Vincent, Angela
通讯作者：
Vincent, Angela
影响因子：
9.9
作者：
Proebstel, A. K.;Dornmair, K.;Derfuss, T.
通讯作者：
Derfuss, T.
影响因子：
48
作者：
Dalmau, Josep;Gleichman, Amy J.;Hughes, Ethen G.;Rossi, Jeffrey E.;Peng, Xiaoyu;Lai, Meizan;Dessain, Scott K.;Rosenfeld, Mynna R.;Balice-Gordon, Rita;Lynch, David R.
通讯作者：
Lynch, David R.
影响因子：
11.2
作者：
Brilot, Fabienne;Dale, Russell C.;Hemmer, Bernhard
通讯作者：
Hemmer, Bernhard