In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes
In Vitro Interactions between Antifungals and Immunosuppressive Drugs against Zygomycetes
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DOI：
10.1128/aac.00184-09
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发表时间：
2009-08-01
影响因子：
4.9
通讯作者：
Lortholary, Olivier
中科院分区：
文献类型：
--
作者：
Dannaoui, Eric;Schwarz, Patrick;Lortholary, Olivier
抗真菌药物与免疫抑制药物的体外相互作用针对放线菌进行了评价。阿替霉素B与环孢霉素、雷帕霉素或他克莫司的组合分别对90%、70%和30%的分离株具有协同作用。对于泊沙康唑、伊曲康唑和拉夫康唑，与环孢霉素相比，更经常观察到协同作用，而与雷帕霉素或他克莫司相比，很少观察到拮抗相互作用。总之，钙调神经磷酸酶抑制剂和雷帕霉素可以在体外与阿替霉素B和唑类化合物协同对抗放线菌。
The in vitro interaction of antifungals with immunosuppressive drugs was evaluated against zygomycetes. The combination of amphotericin B with cyclosporine, rapamycin, or tacrolimus was synergistic for 90%, 70%, and 30% of the isolates, respectively. For posaconazole, itraconazole, and ravuconazole, synergy was more frequently observed with cyclosporine than with rapamycin or tacrolimus and antagonistic interactions were rarely noted. In summary, calcineurin inhibitors and rapamycin can be synergistic in vitro with amphotericin B and azoles against zygomycetes.