C-reactive protein and neopterin levels in healthy non-obese adults
C-reactive protein and neopterin levels in healthy non-obese adults
复制标题
DOI：
10.1515/cclm.2006.055
复制
发表时间：
2006-03-01
影响因子：
6.8
通讯作者：
Bayindir, O
中科院分区：
文献类型：
--
作者：
Bozdemir, AE;Barutcuoglu, B;Bayindir, O
背景资料：肥胖和腰臀比增加，强调躯干肥胖的重要性，已被发现与心血管疾病风险和死亡率增加呈正相关。由于动脉粥样硬化的炎症性质，我们研究的目的是找到健康瘦和超重成人的体重指数和腰臀比，以及炎症标志物C反应蛋白（CRP）和新喋呤之间可能的相关性。方法：共49名健康成人（平均年龄42.4 ± 1.8岁，32名女性和17名男性）根据他们的体重指数（BMI）和腰臀比值进行分类。结果：与BMI < 25 kg/m2的组相比，BMI >= 25 kg/m2的组的CRP水平显著升高（p = 0.014）。与腰臀比< 0.9的受试者相比，腰臀比增加的受试者显示出显著更高的血清CRP和新蝶呤水平（分别为p = 0.014和p=0.033）。CRP和BMI在整个组中呈强正相关（r=0.658，p=0.0001）。结论：根据腰臀比（躯干肥胖的指标）确定超重受试者，似乎便于研究与脂肪组织升高相关的炎症过程。CRP和新蝶呤水平升高可能有助于评估超重和肥胖受试者的心血管风险。
Background: Obesity and increased waist-to-hip ratio, emphasizing the importance of truncal obesity, have been found to correlate positively with increased cardiovascular disease risk and mortality. Owing to the inflammatory nature of atherosclerosis, the aim of our study was to find possible correlations between body mass index and waist-to-hip ratio, and the inflammatory markers C-reactive protein (CRP) and neopterin in healthy lean and overweight adults.Methods: A total of 49 healthy adults ( mean age 42.4 +/- 1.8 years, 32 females and 17 males) were classified according to their body mass index (BMI) and waist-to-hip ratio values. CRP and neopterin levels were measured.Results: CRP levels were found to be significantly higher in the group with BMI >= 25 kg/m(2) compared to the group with BMI < 25 kg/m(2) ( p = 0.014). Subjects with increased waist-to-hip ratio displayed significantly higher serum CRP and neopterin levels (p = 0.014 and p=0.033, respectively) compared with the group in which the waist-to-hip ratio was < 0.9. A strong positive correlation was found between CRP and BMI in the whole group ( r=0.658, p=0.0001).Conclusions: Grouping overweight subjects according to their waist-to-hip ratio, which is an indicator of truncal obesity, seems to be convenient in studying the inflammatory process in relation to the elevation of adipose tissue. Elevated CRP and neopterin levels may be useful in the assessment of cardiovascular risk in overweight as well as obese subjects.