Alcohol, dementia, and Alzheimer's disease: Comparison of neuropsychological profiles
Alcohol, dementia, and Alzheimer's disease: Comparison of neuropsychological profiles
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DOI：
10.1177/089198870001300308
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发表时间：
2000-09-01
影响因子：
2.6
通讯作者：
McNeil, MA
中科院分区：
文献类型：
--
作者：
Saxton, J;Munro, CA;McNeil, MA
39个解毒的老年酗酒者（平均年龄= 65.85）完成了一项全面的评估，旨在确定个人符合DSM-TV标准的酒精相关性痴呆。10例受试者符合标准（平均年龄69.8岁，平均简易精神状态检查（MMSE）= 25.1）与29名非痴呆酗酒者进行了比较。（平均年龄= 64.5;平均MMSE = 27.8），9例阿尔茨海默病患者（平均年龄= 73.4;平均MMSE = 22.3）和15名对照受试者（平均年龄= 70.8;平均MMSE = 28）。神经心理测试分数的比较显示了几个统计学上的显着差异。此外，两个痴呆症组之间的测试性能的整体模式是不同的。阿尔茨海默氏症患者在对抗命名、识别记忆、动物流畅性和定向方面受损更严重。酒精性痴呆受试者在首字母流畅性、精细运动控制和自由回忆方面比对照组受损更严重。然而，酒精痴呆受试者在言语识别记忆测试中与对照组没有差异。这项研究表明，它是可能的临床区分酒精相关的痴呆症的认知缺陷从典型的阿尔茨海默氏病。然而，结果是初步的，并且基于小样本量，因此应谨慎解释。
Thirty-nine detoxified elderly alcoholics (mean age = 65.85) completed a comprehensive assessment designed to identify individuals meeting DSM-TV criteria for alcohol-related dementia. Ten subjects meeting criteria (mean age = 69.8; mean Mini-Mental State Examination [MMSE] = 25.1) were compared to the 29 nondemented alcoholics (mean age = 64.5; mean MMSE = 27.8), 9 patients with Alzheimer's disease (mean age = 73.4; mean MMSE = 22.3), and 15 control subjects (mean age = 70.8; mean MMSE = 28). Comparison of neuropsychological test scores revealed several statistically significant differences. Furthermore, the overall pattern of test performance between the two demented groups was different. Alzheimer's patients were more impaired on confrontation naming, recognition memory, animal fluency, and orientation. Alcohol dementia subjects were more impaired than controls on initial letter fluency, fine motor control, and free recall. However, alcohol dementia subjects did not differ from controls on tests of verbal recognition memory. This study suggests that it is possible to clinically differentiate the cognitive deficits of alcohol-related dementia from typical Alzheimer's disease. However, the results are preliminary and are based on small sample sizes so should be interpreted with caution.