Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts.
Nuclear translocation of insulin receptor substrate-1 by the insulin receptor in mouse embryo fibroblasts.
复制标题
小鼠胚胎成纤维细胞中胰岛素受体对胰岛素受体底物 1 的核易位。
DOI：
10.1002/jcp.10261
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Baserga,Renato
中科院分区：
文献类型：
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作者：
Wu,An;Sciacca,Laura;Baserga,Renato
据报道，胰岛素受体底物- 1 （IRS - 1）向细胞核的易位发生在受胰岛素样生长因子- 1 （IGF - 1）刺激或表达某些病毒和细胞癌基因的细胞中。我们在这里表明，胰岛素也可以诱导不表达1型胰岛素样生长因子受体（IGF - IR）的小鼠胚胎成纤维细胞（MEF）中IRS - 1的核易位。只有胰岛素受体（IR）的A异构体可以诱导IRS - 1核易位，当受体过表达时，这是显著的。在生理受体水平上，易位只发生在一小部分细胞中，并且只发生在高浓度的配体中。©2003 Wiley‐Liss, Inc。
Translocation of the insulin receptor substrate‐1 (IRS‐1) to the nuclei has been reported to occur in cells stimulated by insulin‐like growth factor‐1 (IGF‐I) or expressing certain viral and cellular oncogenes. We show here that insulin can also induce nuclear translocation of IRS‐1 in mouse embryo fibroblasts (MEF), that do not express the type 1 insulin‐like growth factor receptor (IGF‐IR). Only the A isoform of the insulin receptor (IR) can induce IRS‐1 nuclear translocation, which is significant when the receptor is over‐expressed. At physiological receptor levels, translocation occurs only in a fraction of cells, and only at high concentrations of ligand. © 2003 Wiley‐Liss, Inc.