Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
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DOI：
10.1016/s0014-5793(98)01514-2
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发表时间：
1998-12-11
期刊：
影响因子：
3.5
通讯作者：
Tanaka, N
中科院分区：
文献类型：
--
作者：
Sato, M;Hata, N;Tanaka, N
干扰素调节因子（IRF）家族的转录因子调节干扰素（IFN）系统，其中IRF-3参与病毒诱导的IFN-β基因表达。在这里，我表明另一个成员IRF-7是IFN-α基因诱导的关键。与IRF-3基因不同，IRF-7基因由IFN通过激活ISGF 3转录因子诱导，并且IRF-7经历病毒诱导的核转位。在缺乏p48（IFN刺激基因因子3（ISGF 3）的重要成分）的细胞中，IRF-7而不是IRF-3的异位表达可以挽救诱导IFN-α基因的缺陷。这些结果表明IRF-7是IFN-α/β产生的正反馈调节中的关键因子。(C)1998年欧洲生物化学学会联合会。
The interferon regulatory factor (IRF) family of transcription factors regulate the interferon (IFN) system, among which IRF-3 is involved in the virus-induced IFN-beta gene expression. Here me show that another member IRF-7 is critical for the IFN-alpha gene induction. Unlike the IRF-3 gene, the IRF-7 gene is induced by IFNs through activation of the ISGF3 transcription factor, and IRF-7 undergoes virus-induced nuclear translocation. In cells lacking p48, an essential component of IFN stimulated gene factor 3 (ISGF3), ectopic expression of IRF-7 but not IRF-3 can rescue the deficiency to induce IFN-alpha genes. These results indicate that IRF-7 is a key factor in the positive feedback regulation of IFN-alpha/beta production. (C) 1998 Federation of European Biochemical Societies.