Double network hydrogels prepared from pH-responsive doubly crosslinked microgels
Double network hydrogels prepared from pH-responsive doubly crosslinked microgels
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DOI：
10.1039/c3sm51356d
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发表时间：
2013-01-01
期刊：
影响因子：
3.4
通讯作者：
Saunders, Brian R.
中科院分区：
文献类型：
--
作者：
Lane, Thomas;Holloway, Julianne L.;Saunders, Brian R.
双交联（DX）微凝胶是由共价连接的微凝胶组成的宏观水凝胶。以丙烯酰胺（AAm）/N，N '-亚甲基双丙烯酰胺（MBAAm）共聚单体溶液为溶胀剂，将pH响应性的聚（丙烯酸乙酯-甲基丙烯酸-1，4-丁二醇二丙烯酸酯）（PEA-MAA-BDD）微凝胶溶胀，得到双网络双交联微凝胶（DN DX microgel）。在干燥状态下，DN DX微凝胶含有约85体积%的PAAm-co-MBAAm和15体积%的DX微凝胶。的DN DX微凝胶显示其机械性能的重大改进相比，母DX微凝胶和不太明显的pH值引发的溶胀变化。使用动态流变学和压缩应力与应变测量研究凝胶的机械性能。与母体DX微凝胶相比，新的DN DX微凝胶具有大大改善的剪切和压缩模量（435 kPa）、屈服应变和韧性（105 kJ m（-3））。通过提高我们的DX微凝胶的模量和延展性，双网络方法为DX微凝胶在高负荷环境中作为可植入生物材料以及膜的未来应用提供了改进的潜力。
Doubly crosslinked (DX) microgels are macroscopic hydrogels comprised of covalently inter-linked microgels. In this study pH-responsive DX microgels comprised of pH-responsive poly(ethylacrylate-co-methacrylic acid-co-1,4-butanediol diacrylate) (PEA-MAA-BDD) microgels were swollen with an acrylamide (AAm)/N,N'-methylenebisacrylamide (MBAAm) co-monomer solution which was copolymerised to give double network doubly crosslinked microgels (DN DX microgel). The DN DX microgels contained about 85 vol% of PAAm-co-MBAAm and 15 vol% DX microgel in the dry state. The DN DX microgels showed major improvements of their mechanical properties compared to the parent DX microgels and less pronounced pH-triggered swelling changes. The gel mechanical properties were investigated using dynamic rheology and compression stress vs. strain measurements. The new DN DX microgels had much improved shear and compression modulus (435 kPa), yield strains and toughness (105 kJ m(-3)) compared to the parent DX microgels. By improving both the modulus and ductility of our DX microgels, the double network approach offers improved potential for future application of DX microgels as implantable biomaterials in high load environments as well as membranes.