The use of hydrogels in bone-tissue engineering
The use of hydrogels in bone-tissue engineering
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DOI：
10.4317/medoral.16.e115
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发表时间：
2011-01-01
影响因子：
2.2
通讯作者：
Park, Jun-Beom
中科院分区：
文献类型：
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作者：
Park, Jun-Beom
许多不同类型的支架材料已被用于组织工程应用，水凝胶形成了一组已在各种应用中使用的材料。水凝胶是一种亲水性聚合物网络，在生物技术和医学领域是一类重要的生物材料，因为许多水凝胶具有良好的生物相容性，炎症反应和组织损伤最小。许多研究已经证明了水凝胶在骨组织工程中的应用。在这篇报道中，总结了各种聚合物和水凝胶的不同改性方法来促进骨形成。结果表明，水凝胶可用于骨再生，用生物活性分子或基于细胞的方法修饰水凝胶可显著增加新骨的形成。这表明，改性水凝胶的使用可能为骨组织工程提供一种选择，需要进一步研究确定水凝胶的生物和物理性质。
Many different types of scaffold materials have been used for tissue engineering applications, and hydrogels form one group of materials that have been used in a wide variety of applications. Hydrogels are hydrophilic polymer networks and they represent an important class of biomaterials in biotechnology and medicine because many hydrogels exhibit excellent biocompatibility with minimal inflammatory responses and tissue damage. Many studies have demonstrated the use of hydrogels in bone-tissue engineering applications. In this report, the summary was conducted on various kinds of polymers and different modification methods of hydrogels to enhance bone formation.The results revealed that hydrogels are applied for bone regeneration and that the modification of hydrogels with bioactive molecules or cell-based approaches resulted in significant increases in new bone formation. This suggests that the use of hydrogels with modification may offer an option for bone-tissue engineering, and further research is needed to identify the biological and physical properties of hydrogels.