S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease
S-Persulfidation: Chemistry, Chemical Biology, and Significance in Health and Disease
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DOI：
10.1089/ars.2019.7889
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发表时间：
2019-10-25
影响因子：
6.6
通讯作者：
Xian, Ming
中科院分区：
文献类型：
--
作者：
Yang, Chun-tao;Devarie-Baez, Nelmi O.;Xian, Ming
Recent Advances: Some mechanisms underlying the generation of low-molecular-weight persulfides and protein S-persulfidation in living organisms have been uncovered. Some methods for the specific delivery of persulfides and the detection of persulfides in biological systems have been developed. These advances help to pave the road to better understand the functions of S-persulfidation. Critical Issues: Persulfides are highly reactive and unstable. Currently, their identification relies on trapping them by S-alkylation, but this is not always reliable due to rapid sulfur exchange reactions. Therefore, the presence, identity, and fates of persulfides in biological environments are sometimes difficult to track. Future Directions: Further understanding the fundamental chemistry/biochemistry of persulfides and development of more reliable detection methods are needed. S-Persulfidation in specific protein targets is essential in organismal physiological health and human disease states. Besides cardiovascular and neuronal systems, the roles of persulfidation in other systems need to be further explored. Contradictory results of persulfidation in biology, especially in cancer, need to be clarified.
