Detection of maternofetal transfusion by placental alkaline phosphatase levels
Detection of maternofetal transfusion by placental alkaline phosphatase levels
复制标题
DOI：
10.1016/s0022-3476(97)80014-5
复制
发表时间：
1997-05-01
影响因子：
5.1
通讯作者：
Nagata, I
中科院分区：
文献类型：
--
作者：
Kaneda, T;Shiraki, K;Nagata, I
我们通过测量胎盘碱性磷酸酶（FLAP）作为胎盘通过的指标来研究母胎输血量。在 135 对母婴血清中测量了 FLAP 水平。估计母胎输血量按下式计算：输血量（毫升）= 85 ml/kg x BW（公斤）x (PLAP(AB) - PLAP(1MO))/ PLAP(MA)，其中 BW 为出生体重，PLAP(AB) 为出生时新生儿血清中的 FLAP 水平，PLAP(1MO) 为新生儿出生时的 PLAP 水平。 1月龄新生儿血清，PLAP(MA)是分娩时母体血清中的PLAP水平。平均PLAP(MA)、PLAP(AB)和PLAP(1MO)水平分别为276.95 +/- 159.74 IU/L、3.83 +/- 2.17 IU/L和0.25 +/- 0.22 IU/L。母胎输血的平均体积估计为3.33 +/- 1.68 ml。计划剖腹产的每公斤出生体重的母胎输血平均估计量（0.74 +/- 0.35 ml/kg）显着低于阴道分娩（1.18 +/- 0.54 ml/kg；p < 0.001）和紧急剖腹产（1.73 +/- 1.00 ml/kg；p < 0.01）。在计划剖宫产中，观察到胎龄与每公斤出生体重的估计输血量之间存在显着的正相关性。在阴道分娩的情况下，短产程组（< 5小时：0.92 +/- 0.32 ml/kg）每公斤出生体重的估计输血量显着高于产程长组（大于或等于5小时：1.29 +/- 0.61 ml/kg；p < 0.001）。 PLAP 被认为可用于估计母胎输血量。转移量似乎与子宫收缩和胎盘随老化的组织学变化有关。
We investigated the volume of maternofetal transfusion by measuring placental alkaline phosphatase (FLAP) as an indicator of placental passage. FLAP levels were measured in 135 pairs of maternal-neonatal sera. Estimated volumes of maternofetal transfusion were calculated with the following formula: Volume of transfusion (in milliliters) = 85 ml/kg x BW (in kilograms) x (PLAP(AB) - PLAP(1MO))/ PLAP(MA), where BW is the birth weight, PLAP(AB) is the FLAP level in neonatal serum at birth, PLAP(1MO) is the PLAP level in neonatal serum at 1 month of age, and PLAP(MA) is the PLAP level in maternal serum at delivery. The mean PLAP(MA), PLAP(AB), and PLAP(1MO) levels were 276.95 +/- 159.74 IU/L, 3.83 +/- 2.17 IU/L, and 0.25 +/- 0.22 IU/L, respectively, The mean volume of maternofetal transfusion was estimated to be 3.33 +/- 1.68 ml. The mean estimated volume of maternofetal transfusion per kilogram of birth weight was significantly lower in cases of scheduled cesarean delivery (0.74 +/- 0.35 ml/kg) than in cases of vaginal delivery (1.18 +/- 0.54 ml/kg; p < 0.001) and emergency cesarean delivery (1.73 +/- 1.00 ml/kg; p < 0.01). In scheduled cesarean delivery a significant positive correlation between gestational age and the estimated volumes of transfusion per kilogram of birth weight was observed. in cases of vaginal delivery, the estimated volume of transfusion per kilogram of birth weight was significantly Bower in the group with short labor (< 5 hours: 0.92 +/- 0.32 ml/kg) than in the group with prolonged labor (greater than or equal to 5 hours: 1.29 +/- 0.61 ml/kg; p < 0.001). PLAP was considered to be useful for estimating the volume of maternofetal transfusion. The transfer volume appeared to relate to uterine contractions and to histologic changes in the placenta with aging.