Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance
Hydroxy double salts loaded with bioactive ions: Synthesis, intercalation mechanisms, and functional performance
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DOI：
10.1016/j.jssc.2016.03.019
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发表时间：
2016-06
影响因子：
3.3
通讯作者：
A. Kaassis;Si-Min Xu;S. Guan;D. Evans;Min Wei;Gareth R. Williams
中科院分区：
文献类型：
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作者：
A. Kaassis;Si-Min Xu;S. Guan;D. Evans;Min Wei;Gareth R. Williams
研究了双氯芬酸（Dic）、萘普生（Nap）和丙戊酸（瓦尔）阴离子对三羟基复盐（HDS）的插层作用。以[Co1.2Zn3.8（OH）8]（NO3）2·2 H2O（CoZn-NO3）、[Ni 2 Zn 3（OH）8]（NO3）2·2 H2O（NiZn-NO3）和[Zn 5（OH）8]（NO3）2·2 H2O（Zn-NO3）为催化剂进行了实验研究。证明可以将双氯芬酸和萘普生嵌入所有三种HDS中。而瓦尔可以插层到CoZn-NO3中，但当与Zn-NO3反应时，HDS结构被破坏，产物中含有ZnO。通过X射线衍射、红外光谱和元素分析证实了插层成功。分子动力学模拟表明，Dic和Nap离子在层间空间中以“X”形排列，形成双层。发现瓦尔采用其脂族基团平行于HDS层的位置，再次在双层中。原位时间分辨X射线衍射实验表明，Dic和Nap嵌入CoZn-NO3和Zn-NO3的机理复杂，并观察到许多中间相。相反，所有三种客体插入NiZn-NO 3和瓦尔插入CoZn-NO 3是简单的一步反应，直接从起始材料进行到产物。HDS-药物复合物被发现具有持续释放曲线。
The intercalation of the anions of diclofenac (Dic), naproxen (Nap), and valproic acid (Val) into three hydroxy double salts (HDSs) has been explored in this work. Experiments were performed with [Co1.2Zn3.8(OH)8](NO3)2·2H2O (CoZn-NO3), [Ni2Zn3(OH)8](NO3)2·2H2O (NiZn-NO3) and [Zn5(OH)8](NO3)2·2H2O (Zn-NO3). It proved possible to intercalate diclofenac and naproxen into all three HDSs. In contrast, Val could be intercalated into CoZn-NO3but when it was reacted with Zn-NO3the HDS structure was destroyed, and the product comprised ZnO. Successful intercalation was verified by X-ray diffraction, IR spectroscopy, and elemental microanalysis. Molecular dynamics simulations showed the Dic and Nap ions to arrange themselves in an “X” shape in the interlayer space, forming a bilayer. Val was found to adopt a position with its aliphatic groups parallel to the HDS layer, again in a bilayer. In situ time resolved X-ray diffraction experiments revealed that intercalation of Dic and Nap into CoZn-NO3and Zn-NO3is mechanistically complex, with a number of intermediate phases observed. In contrast, the intercalation of all three guests into NiZn-NO3and of Val into CoZn-NO3are simple one step reactions proceeding directly from the starting material to the product. The HDS-drug composites were found to have sustained release profiles.