Physiologic dysfunction of the asthmatic lung: what's going on down there, anyway?
Physiologic dysfunction of the asthmatic lung: what's going on down there, anyway?
复制标题
DOI：
10.1513/pats.200808-091rm
复制
发表时间：
2009-05-01
期刊：
影响因子：
--
通讯作者：
Bates, Jason H T
中科院分区：
文献类型：
--
作者：
Irvin, Charles G;Bates, Jason H T
哮喘是一种以气流阻塞、支气管扩张剂可逆性和气道高反应性（AHR）为特征的肺功能障碍综合征。越来越多的证据表明，哮喘的主要缺陷是气道腔被液体、纤维蛋白和粘液阻塞。在哮喘中观察到的FEV（1）的下降最好解释为交通气隙的丧失和残余肺容量的增加。对人类患者和实验动物的成像研究都支持这一假设。气道关闭的倾向增加可能是AHR的原因。我们的结论是，肺容量的损失在确定哮喘肺功能障碍中起着核心作用，通过FEV（1）测量。总之，这些最新的研究结果提供了一个更好的了解气流阻塞和AHR的原因，为开发更有效的哮喘治疗提供了新的途径。
Asthma is a syndrome of lung dysfunction characterized by airflow obstruction, reversibility to bronchodilators, and airways hyperresponsiveness (AHR). There is a growing body of evidence that suggests that the principle defect in asthma is the occlusion of the airway lumen by liquid, fibrin, and mucus. The fall in FEV(1) observed in asthma is best explained by a loss of communicating airspaces and the rise in residual lung volume. Imaging studies in both human patients and experimental animals support this hypothesis. An increased propensity for the airways to close can be a cause of AHR. We conclude that loss of lung volume plays a central role in determining the dysfunction of the asthmatic lung as measured by FEV(1). Together, these recent findings provide a better understanding of the causes of airflow obstruction and AHR, suggesting new avenues for the development of more effective asthma therapies.