Serology of acute exacerbation in chronic hepatitis B virus infection.
Serology of acute exacerbation in chronic hepatitis B virus infection.
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DOI：
10.1016/0016-5085(93)90960-k
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发表时间：
1993-10
期刊：
影响因子：
29.4
通讯作者：
T. Maruyama;S. Iino;K. Koike;K. Yasuda;D. Milich
中科院分区：
文献类型：
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作者：
T. Maruyama;S. Iino;K. Koike;K. Yasuda;D. Milich
背景：许多慢性B型肝炎患者的肝损伤是散发性的，其特征通常是急性加重与相对正常的肝功能交替。本研究的目的是在活动性肝病期间进行详细的血清学和生化分析，以更好地了解肝损伤周期性的机制。方法：对19例B e抗原（HBeAg）阳性患者的一系列血清样本进行分析，以了解自发性肝损伤急性加重前、期间和之后血清B病毒（HBV）DNA、HBeAg、抗-HBe产生和HBeAg特异性免疫复合物形成的变化。结果：该分析揭示了血清HBV DNA、HBeAg、HBeAg特异性免疫复合物水平升高与肝损伤之间的显著相关性。这些结果表明，增加病毒复制和积累的病毒蛋白在血清和细胞内和随后的免疫反应中起着重要的作用，在启动急性加重的肝损伤慢性肝炎B infection.Conclusions：我们建议，生产的分泌和细胞形式的核蛋白达到阈值水平和elaries特异性免疫反应，介导肝损伤。
Background:Liver injury in many patients with chronic hepatitis B is sporadic and is often characterized by acute exacerbations alternating with relatively normal liver function. The aim of this study was to perform detailed serological and biochemical analysis during periods of active liver disease to better understand the mechanisms responsible for the cyclic nature of liver injury.Methods:A series of serum samples from 19 hepatitis B e antigen (HBeAg)-positive patients were analyzed for alterations in serum hepatitis B virus (HBV) DNA, HBeAg, anti-HBe production, and HBeAg-specific immune complex formation before, during, and after spontaneous acute exacerbations of liver injury.Results:This analysis revealed significant correlations between increasing levels of serum HBV DNA, HBeAg, HBeAg-specific immune complexes, and liver injury. These results suggest that increases in viral replication and accumulation of viral proteins in the serum and intracellularly and the subsequent immune response play an important role in initiating acute exacerbations of liver injury in chronic hepatitis B infection.Conclusions:We propose that production of the secreted and cellular forms of the nucleoprotein reaches a threshold level and elicits specific immune responses, which mediate liver injury.