New Reagents and Synthetic Approaches to the Appel Reaction
New Reagents and Synthetic Approaches to the Appel Reaction
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DOI：
10.2174/1570179412666150305231358
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发表时间：
2015-01-01
影响因子：
1.8
通讯作者：
de Mattos, Marcio C. S.
中科院分区：
文献类型：
--
作者：
de Andrade, Vitor S. C.;de Mattos, Marcio C. S.
在三苯基膦和四卤化碳存在下醇转化为卤代烷的反应（通常称为阿佩尔反应）是在温和和中性条件下卤化的重要途径。在过去的二十年中，阿佩尔反应经历了相当大的演变。尽管四卤化碳的使用减少，但已经开发并应用了几种方便的试剂作为亲电卤素源。此外，改进的Appel型反应允许合成烷基卤以及硫氰酸酯、硝酸酯、亚硝酸酯、酰胺、酯和酰基卤。不同的合成方法，以减少副产物废物从阿佩尔反应已在文献中报道，并在本文中介绍。本文综述了近年来在Appel型反应中使用新试剂和合成方法的研究进展。
The conversion of alcohol to alkyl halide in the presence of triphenylphosphine and carbon tetrahalide, which is commonly known as the Appel reaction, is an important route for halogenations under mild and neutral conditions. During the past twenty years, the Appel reaction has experienced a considerable evolution. Several convenient reagents have been developed and applied as electrophilic halogen sources despite a decline in the use of carbon tetrahalides. In addition, modified Appel-type reactions allow for the synthesis of alkyl halides as well as thiocyanates, nitrates, nitrites, amides, esters and acyl halides. Different synthetic methodologies to reduce the by-product waste from the Appel reaction have been reported in the literature and are presented in this paper. Herein, this review will present recent achievements in the use of novel reagents and synthetic procedures for Appel-type reactions.