Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist.
Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist.
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DOI：
10.1007/s11154-017-9411-6
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发表时间：
2017-06
影响因子：
8.2
通讯作者：
Savastano S
中科院分区：
文献类型：
--
作者：
Barrea L;Savanelli MC;Di Somma C;Napolitano M;Megna M;Colao A;Savastano S
牛皮癣是一种慢性免疫介导的炎症性皮肤病。银屑病病变的特征是表皮角质形成细胞过度增殖，并伴有真皮和表皮中的炎性细胞浸润。表皮是通过阳光作用合成维生素 D 的天然来源。最近，据报道维生素 D 在包括牛皮癣在内的不同皮肤病的发病机制中发挥着作用。事实上，低维生素 D 状态与牛皮癣之间的显着关联已被系统地观察到。由于其在角质细胞增殖和成熟中的作用，维生素 D 已成为治疗牛皮癣的重要局部治疗选择。迄今为止，基于膳食摄入足够的维生素 D 或口服维生素 D 补充剂来成功治疗银屑病的临床需求尚未得到满足，其有益效果的证据仍存在争议。这些信息对于皮肤科医生和营养学家来说非常重要，可以增加对低维生素 D 状态与银屑病之间可能存在的双向关系的了解，以及维生素 D 在银屑病中的潜在用途，其目的不仅是降低其临床严重程度，而且还可以描述银屑病可能导致的合并症心脏危险因素的风险状况。在当前的综述中，我们分析了银屑病疾病和维生素 D 之间可能存在的双向联系。
Psoriasis is a chronic immune-mediated inflammatory skin disease. Psoriasis lesions are characterized by hyper-proliferation of epidermal keratinocytes associated with inflammatory cellular infiltrate in both dermis and epidermis. The epidermis is the natural source of vitamin D synthesis by sunlight action. Recently, a role for vitamin D in the pathogenesis of different skin diseases, including psoriasis, has been reported. Indeed, significant associations between low vitamin D status and psoriasis have been systematically observed. Due to its role in proliferation and maturation of keratinocytes, vitamin D has become an important local therapeutic option in the treatment of psoriasis. To date, the successful treatment based on adequate dietary intake of vitamin D or oral vitamin D supplementation in psoriasis represent an unmet clinical need and the evidence of its beneficial effects remains still controversial. This information is important either for Dermatologists and Nutritionists to increases the knowledge on the possible bi-directional relationships between low vitamin D status and psoriasis and on the potential usefulness of vitamin D in psoriasis with the aim not only to reduce its clinical severity, but also for delineating the risk profile for co-morbidities cardiac risk factors that may result from psoriasis. In the current review, we analyzed the possible bi-directional links between psoriatic disease and vitamin D.