Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.
Mitotic redistribution of the mitochondrial network by Miro and Cenp-F.
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DOI：
10.1038/ncomms9015
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发表时间：
2015-08-11
影响因子：
16.6
通讯作者：
Kornmann B
中科院分区：
文献类型：
--
作者：
Kanfer G;Courthéoux T;Peterka M;Meier S;Soste M;Melnik A;Reis K;Aspenström P;Peter M;Picotti P;Kornmann B
Although chromosome partitioning during mitosis is well studied, the molecular mechanisms that allow proper segregation of cytoplasmic organelles in human cells are poorly understood. Here we show that mitochondria interact with growing microtubule tips and are transported towards the daughter cell periphery at the end of mitosis. This phenomenon is promoted by the direct and cell cycle-dependent interaction of the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F. Cenp-F is recruited to mitochondria by Miro at the time of cytokinesis and associates with microtubule growing tips. Cells devoid of Cenp-F or Miro show decreased spreading of the mitochondrial network as well as cytokinesis-specific defects in mitochondrial transport towards the cell periphery. Thus, Miro and Cenp-F promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells. During mitosis, mitochondria partition into daughter cells through microtubule-based transport. Here the authors show that the mitochondrial protein Miro and the cytoskeletal-associated protein Cenp-F interact in a cell-cycle dependent manner to promote microtubule-directed movement of mitochondria.
