Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials.
Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials.
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DOI：
10.1093/nutrit/nuv012
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发表时间：
2015-09
影响因子：
6.1
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Chandler PD;Wang L;Zhang X;Sesso HD;Moorthy MV;Obi O;Lewis J;Prince RL;Danik JS;Manson JE;LeBoff MS;Song Y
评估单独补充维生素D或与钙一起补充会改变肥胖指标。对MEDLINE、EMBASE和Cochrane随机临床试验(RCT)进行系统研究(1966年至2014年3月)，研究对象为50名≥患者，年龄18岁，治疗至少12周。主要终点是体重、体重指数(BMI)或脂肪质量(FM)的变化。在确定的953项试验中，26项随机对照试验(12项：仅维生素D；10项：维生素D加钙与钙对照；4项：维生素D加钙与安慰剂)符合纳入标准；42,430名参与者(中位持续时间：12个月)。单独补充维生素D与服用安慰剂相比：体重指数(加权平均差：−0.06公斤/平方米，95%可信区间：−0.14，0.03)、体重(加权平均偏差：−0.05公斤，95%可信区间：−0.32，0.23)或FM(加权平均偏差：−0.43公斤，95%可信区间：−1.69，0.84)没有显著变化。维生素D加钙与钙对照：体重指数(体重密度：0.02公斤/平方米，95%可信区间：−0.11，0.14)、体重(体重密度：0.12公斤，95%可信区间：−0.24，0.49)或调脂(体重密度：0.12公斤，95%可信区间：−0.22，0.45)无显著差异；维生素D对成年人的肥胖测量没有影响。
Assess vitamin D supplementation alone or with calcium alters adiposity measures. Systematic search (1966-March 2014) of MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for randomized clinical trials (RCTs) with >50 participants aged ≥18 years at baseline and at least 12 weeks of treatment. Primary end points were changes in weight, body mass index (BMI), or fat mass (FM). Of 953 trials identified, 26 RCTs (12:Vitamin D alone; 10: Vitamin D plus calcium versus calcium control; 4:Vitamin D plus calcium versus placebo) met the inclusion criteria; 42,430 participants (median duration: 12 months). Vitamin D supplementation alone versus placebo: no significant change in BMI (weighted mean difference (WMD): −0.06 kg/m2, 95% CI: −0.14,0.03), weight (WMD: −0.05 kg, 95% CI:−0.32,0.23) or FM (WMD: −0.43 kg, 95% CI: −1.69,0.84). Vitamin D plus calcium versus calcium control: no significant reduction in BMI (WMD: 0.02 kg/m2, 95% CI: −0.11, 0.14), weight (WMD: 0.12 kg, 95% CI: −0.24, 0.49), or FM (WMD: 0.12 kg, 95% CI: −0.22, 0.45); no significant heterogeneity. Vitamin D showed no effect on adiposity measures in adults.