Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer.
Tumor purity as a prognosis and immunotherapy relevant feature in cervical cancer.
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肿瘤纯度作为宫颈癌的预后和免疫治疗相关特征
DOI：
10.18632/aging.203714
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发表时间：
2021-11-29
期刊：
影响因子：
--
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Deng Y;Song Z;Huang L;Guo Z;Tong B;Sun M;Zhao J;Zhang H;Zhang Z;Li G
背景：肿瘤纯度在实体肿瘤的生物学过程中起着至关重要的作用，但其在妇科肿瘤中的作用尚不清楚。本研究旨在探讨肿瘤纯度与妇科肿瘤免疫功能的相关性及其作为免疫治疗预后指标的可靠性。方法：从癌症基因组图谱（TCGA）下载妇科癌症相关数据集。通过ESTIMATE算法计算肿瘤纯度。进行LASSO考克斯回归分析以构建风险评分模型。采用Kaplan-Meier作图法探讨肿瘤纯度与肿瘤预后的关系。我们进行了京都基因和基因组百科全书（KEGG）和基因集富集分析（GSEA），以探索亚组中的途径。用列线图定量评估肿瘤预后。结果：宫颈鳞癌和宫颈腺癌（CESC）的肿瘤纯度与B细胞浸润呈负相关。大约420个基因与B细胞浸润和CESC预后正相关，并在免疫相关信号通路中富集。有11个关键基因用于构建风险评分模型。低危组比高危组免疫评分更高，预后更好。基于危险评分、T分期和临床分期的诺模图对定量评估CESC的预后有较好的预测价值。结论：这项研究首次揭示了CESC中肿瘤纯度与免疫力之间的相关性，并表明低风险患者可能对免疫治疗更敏感。这为临床治疗CESC提供了理论依据。
Background: Tumor purity plays a vital role in the biological process of solid tumors, but its function in gynecologic cancers remains unclear. This study explored the correlation between tumor purity and immune function of gynecological cancers and its reliability as a prognostic indicator of immunotherapy. Methods: Gynecological cancer-related datasets were downloaded from The Cancer Genome Atlas (TCGA). Tumor purity was calculated by the ESTIMATE algorithm. A LASSO Cox regression analysis was performed to construct the risk score model. A Kaplan–Meier Plotter was used to explore the relationships between tumor purity and cancer prognosis. We performed the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Set Enrichment Analysis (GSEA) to explore the pathways in the subgroups. A nomogram was used to quantitatively assess the cancer prognosis. Results: Tumor purity was negatively correlated with B cell infiltration in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC). Approximately 420 genes were positively associated with B cell infiltration and CESC prognosis and were enriched in immune-related signaling pathways. There were 11 key genes used to construct a risk score model. The low-risk group had a higher immune score and better prognosis than the high-risk group. A nomogram based on risk score, T stage, and clinical-stage had good predictive value in quantitatively evaluating CESC prognosis. Conclusions: This study is the first to reveal the correlation between tumor purity and immunity in CESC and suggests that low-risk patients may be more sensitive to immunotherapy. This provides a theoretical basis for the clinical treatment of CESC.
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影响因子：
6.4
作者：
Lippens, Lien;Van Bockstal, Mieke;Denys, Hannelore
通讯作者：
Denys, Hannelore
低肿瘤纯度与结肠癌的不良预后、重突变负担和强烈的免疫表型相关
影响因子：
3.3
作者：
Mao Y;Feng Q;Zheng P;Yang L;Liu T;Xu Y;Zhu D;Chang W;Ji M;Ren L;Wei Y;He G;Xu J
通讯作者：
Xu J
影响因子：
2.7
作者：
Dorani F;Hu T;Woods MO;Zhai G
通讯作者：
Zhai G
影响因子：
7.3
作者：
Qu H;Zhao H;Zhang X;Liu Y;Li F;Sun L;Song Z
通讯作者：
Song Z
影响因子：
7.5
作者：
Ge, Penglei;Wang, Weiwei;Wu, Yang
通讯作者：
Wu, Yang