1-year pulmonary function and health status in survivors of severe acute respiratory syndrome
1-year pulmonary function and health status in survivors of severe acute respiratory syndrome
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DOI：
10.1378/chest.128.3.1393
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发表时间：
2005-09-01
期刊：
影响因子：
9.6
通讯作者：
Earnest, A
中科院分区：
文献类型：
--
作者：
Ong, KC;Ng, AWK;Earnest, A
研究目的：在一个前瞻性鉴定的严重急性呼吸系统综合征（SARS）存活患者队列中，描述其长期肺功能和健康状况。设计：前瞻性随访队列研究。单位：学校附属医院。病人：在出院后1年的统一时间点对94名从SARS中康复的病人进行评估。测量：该研究包括静态和动态肺体积的测量，肺一氧化碳（DLCO）弥散能力的测定，以及使用圣乔治呼吸问卷（SGRQ）进行健康状况评估。结果：FVC轻度损害11例（12%），FEV1轻度损害20例（21%），FEV1/FVC轻度损害5例（5%），DLCO轻度损害17例（18%）。FVC中度损害1例（1%），FEV1/FVC比例中度损害1例（1%），DLCO中度损害3例（3%）。59例（63%）患者未发现肺功能异常。在SGRQ的活动（p < 0.001）、影响（p < 0.001）和总（p < 0.001）域中，平均得分显著高于（即差）总体规范。结论：SARS患者康复一年后，约三分之一的患者存在持续性肺功能障碍。SARS幸存者的健康状况也明显比健康人群差。在康复的SARS患者中，发病率的主要决定因素需要进一步确定。
Study objectives: To characterize the long-term pulmonary, function and health status in a prospectively identified cohort of patients who survived the severe acute respiratory syndrome (SARS).Design: Prospective follow-up cohort study.Setting: University-affiliated hospital.Patients: Ninety-four patients who recovered from SARS were assessed at a uniform time point of I year after hospital discharge.Measurements: The study, included the measurement of static and dynamic lung volumes, the determination of the diffusing capacity, of the lung for carbon monoxide (DLCO), and a health status evaluation using the St. George Respiratory, Questionnaire (SGRQ).Results: Eleven patients (12%) had mild impairment of FVC, 20 (21%) had mild impairment of FEV1, 5 (5%) had mild impairment of the FEV1/FVC ratio, and 17 (18%) had mild impairment of the DLCO. There was one patient (1%) who had moderate impairment of FVC, one patient (1%) who had moderate impairment of the FEV1/FVC ratio, and three patients (3%) who had moderate impairment of the DLCO. No pulmonary, function abnormalities were detected in 59 patients (63%). Mean scores were significantly higher (ie, worse) than the population norms in the activity (p < 0.001), impacts (p < 0.001), and total (p < 0.001) domains of the SGRQ.Conclusions: One year after recovery, from SARS, persistent pulmonary, function impairment was found in about one third of patients. The health status of SARS survivors was also significantly worse compared with the healthy, population. The main determinants of morbidity, in recovered SARS patients need to be further defined.