Neurological improvement in patients with chronic spinal cord injury treated with leuprolide acetate, an agonist of GnRH
Neurological improvement in patients with chronic spinal cord injury treated with leuprolide acetate, an agonist of GnRH
复制标题
DOI：
10.21307/ane-2018-034
复制
发表时间：
2018-01-01
影响因子：
1.4
通讯作者：
Olvera-Sandoval, Carlos
中科院分区：
文献类型：
--
作者：
Luis Quintanar, Jose;Diaz-Galindo, Carmen;Olvera-Sandoval, Carlos
据报道，促性腺激素释放激素（GnRH）及其类似物醋酸leuprolide （LA）具有神经营养特性；特别是在动物模型和脊髓损伤（SCI）患者中受损脊髓的再生。本研究的目的是确定LA治疗是否能改善慢性脊髓损伤患者的敏感性、运动活动和独立性。患者每月接受一次LA治疗，持续6个月。在治疗开始和结束时对他们进行评估；使用敏感度和运动损伤量表，根据美国脊髓损伤协会（ASIA）和独立等级量表；采用脊髓独立性测量（SCIM）。统计分析显示，在LA治疗6个月后，比较初始评估和最终评估时，ASIA感官评分和SCIM评分有显著改善。有些病人表现出排便频率增加。LA治疗可改善慢性脊髓损伤患者的敏感性、运动活动和独立性。该方案的一个优点是它是一种非侵入性的方法，使用简单，安全，副作用少。
It has been reported that gonadotropin-releasing hormone (GnRH), and its analogue leuprolide acetate (LA), have neurotrophic properties; particularly in the regeneration of injured spinal cord in animal models and in the case of a patient with spinal cord injury (SCI). The aim of this study was to establish whether treatment with LA improves sensitivity, motor activity and independence in patients with chronic SCI. Patients were treated LA once a month for six months. They were evaluated at the beginning and at the end of treatment; using a sensitivity and motor impairment scale, according to the American Spinal Injury Association (ASIA), and grade of independence scale; employing the spinal cord independence measure (SCIM). Statistical analysis showed a significant improvement in the ASIA sensory score and the SCIM score when comparing the initial versus final evaluation after six months of LA administration. Some patients showed an increase in frequency of bowel movements. Treatment with LA induces improvements in sensitivity, motor activity and independence in patients with chronic SCI. One advantage of this protocol is that it is a non-invasive method of easy and safe application, with few side effects.