Chronic kidney disease, atherosclerosis, and cognitive and physical function in the geriatric group of the National Health and Nutrition Survey 1999-2002
Chronic kidney disease, atherosclerosis, and cognitive and physical function in the geriatric group of the National Health and Nutrition Survey 1999-2002
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DOI：
10.1016/j.atherosclerosis.2008.04.020
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发表时间：
2009-01-01
期刊：
影响因子：
5.3
通讯作者：
Lin, Jou-Wei
中科院分区：
文献类型：
--
作者：
Lin, Chien-Yu;Lin, Lian-Yu;Lin, Jou-Wei
背景资料：本研究旨在阐明慢性肾脏病（CKD），动脉粥样硬化并发症，和石油功能performance.Methods的影响之间的关系：共2431例年龄在65岁及以上的国家健康和营养调查（NHANES）1999-2002年被纳入制定一项基于人群的观察性研究。结果：在调整潜在混杂因素后，肾功能损害与认知功能和躯体功能独立相关（B =-0.12，p = 0.02）。肾损害与动脉粥样硬化并发症呈正相关（B = 0.26 p < 0.001），而动脉粥样硬化并发症与功能表现呈负相关（B =-0.24，p < 0.001）。方差分析显示，57%的身体和认知功能的差异可以归因于CKD，CKD相关的动脉粥样硬化，以及其他心血管危险因素。结论：CKD可能会直接或间接影响认知和身体功能，通过动脉粥样硬化并发症。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
Background: This Study was designed to elucidate the relationship between chronic kidney disease (CKD), atherosclerotic complications, and the effects oil functional performance in the elderly.Methods: A total of 2431 subjects aged 65 and above from the National Health and Nutrition Survey (NHANES) 1999-2002 were included to formulate a population-based observational Study. A structural equation model (SEM) Was Constructed to validate the relationship between renal impairment, atherosclerotic complications, and cognitive and physical function.Results: The results showed that renal impairment was independently associated with physical and cognitive function after adjustment of potential Confounding factors (B = -0.12, p = 0.02). Renal impairment was positively associated with atherosclerotic complications (B = 0.26 p < 0.001), which was in turn negatively associated with functional performance (B = -0.24, p < 0.001). Variance analysis showed that 57% of the differences in physical and cognitive function could be attributed to CKD, CKD-associated atherosclerosis, and other cardiovascular risk factors.Conclusions: CKD may have impacts on the cognitive and physical function either directly or indirectly via atherosclerotic complications. (C) 2008 Elsevier Ireland Ltd. All rights reserved.