THE ULTRASTRUCTURE OF INTRAMUSCULAR NERVES IN AMYOTROPHIC LATERAL SCLEROSIS
THE ULTRASTRUCTURE OF INTRAMUSCULAR NERVES IN AMYOTROPHIC LATERAL SCLEROSIS
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DOI：
10.1007/bf00691318
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发表时间：
1981-01-01
影响因子：
12.7
通讯作者：
ATSUMI, T
中科院分区：
文献类型：
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作者：
ATSUMI, T
本文报告11例肌萎缩侧索硬化症(ALS)患者的肌肉活检结果。7例术中发现神经，行EM检查。萎缩的肌肉中有髓纤维明显减少。其余有髓轴突的超微结构显示神经细丝、线粒体和小泡均有改变。无髓纤维和有髓纤维数量减少。偶见含有细小轴突的无髓纤维增多。无髓轴突内有淀粉体，无髓纤维雪旺细胞胞外区有带状结构。其中一些发现被认为是I.M.变性和再生的超微结构特征。肌萎缩侧索硬化症运动神经元的神经。
Muscle biopsies of 11 patients suffering from amyotrophic lateral sclerosis (ALS) were examined and the i.m. nerves found in 7 were examined by EM. In atrophied muscles there was a marked decrease of myelinated fibers. The ultrastructure of the remaining myelinated axons showed changes in the neurofilaments, mitochondria and vesicles. There was a decrease in the number of unmyelinated and myelinated fibers. Occasionally there was an increase of unmyelinated fibers containing small fine axons. There were corpora amylacea in unmyelinated axons and banded structures in the extracellular area of the Schwann cells of the unmyelinated fibers. Some of these findings were considered as ultrastructural features of degeneration and regeneration in i.m. nerves of motoneurons in ALS.