Bioactive polyketides from Peperomia duclouxii
Bioactive polyketides from Peperomia duclouxii
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DOI：
10.1021/np070089n
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发表时间：
2007-06-01
影响因子：
5.1
通讯作者：
Ando, Masayoshi
中科院分区：
文献类型：
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作者：
Li, Na;Wu, Jian-lin;Ando, Masayoshi
沿着16个已知化合物，从杜氏椒草全草中分离得到4个新化合物（1-4）。新结构被鉴定为4-羟基-2-[（3，4-亚甲二氧基苯基）壬酰基]环己烷-1，3-二酮（1），4-羟基-2-[（3，4-亚甲二氧基苯基）十一烷酰基]环己烷-1，3-二酮（2），4-羟基-2-[（3，4-亚甲二氧基苯基）十三烷酰基]环己烷-1，3-二酮（3）和2-[（3，4-亚甲二氧基苯基）十二烷基]-4-羟基-2，3，4，6，7，8-六氢-2H-1-苯并吡喃-5-酮（4）。已知的聚酮化合物苏林酮A和奥利菲酮显示出对WI-38、VA-13和HepG 2细胞系的细胞生长抑制活性，IC 50值范围为4.4至9.6 μ g/mL。已知的倍半萜类化合物sinugibberodiol在2.5和25 μ g/mL时对钙黄绿素积累的作用比维拉帕米更强。化合物3和4、苏林酮A和奥利菲酮在IL-1 α或TNF-α存在下对细胞间粘附分子-1（ICAM-1）的诱导显示出中等至弱的抑制活性。
Four new compounds (1-4) were isolated along with 16 known compounds from whole plants of Peperomia duclouxii. The new structures were elucidated as 4-hydroxy-2-[(3,4-methylenedioxyphenyl)nonanoyl]cyclohexane-1,3-dione (1), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (2), 4-hydroxy-2-[(3,4-methylenedioxyphenyl)tridecanoyl]cyclohexane-1,3-dione (3), and 2-[(3,4-methylenedioxyphenyl)dodecyl]-4-hydroxy-2,3,4,6,7,8-hexahydro-2H-1-benzopyran-5-one (4), by analysis of their spectroscopic data. The known polyketides, surinone A and oleiferinone, showed cell growth inhibitory activity against the WI-38, VA-13, and HepG2 cell lines with IC50 values that ranged from 4.4 to 9.6 mu g/mL. The known sesquiterpenoid, sinugibberodiol, showed a more potent effect on calcein accumulation than verapamil at 2.5 and 25 mu g/mL. Compounds 3 and 4, surinone A, and oleiferinone showed moderate to weak inhibitory activity on the induction of the intercellular adhesion molecule-1 (ICAM-1) in the presence of IL-1 alpha or TNF-alpha.