Characteristics of a high molecular weight extracellular protein of Streptococcus mutans.
Characteristics of a high molecular weight extracellular protein of Streptococcus mutans.
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变形链球菌高分子量胞外蛋白的特征。
DOI：
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
K. Knox
中科院分区：
文献类型：
--
作者：
H. Forester;N. Hunter;K. Knox
已从恒化器生长的变形链球菌菌株Ingbritt的培养液中分离出一种高分子量蛋白质抗原，命名为P1，并显示不含其他抗原，包括葡糖基转移酶。在火箭免疫电泳中使用抗蛋白质的抗血清，以确认和扩展先前的观察结果，即在不同生长条件下产生的蛋白质的量存在重大差异。物理化学和血清学研究表明，蛋白质P1与其他实验室分离的抗原B、I/II和IF难以区分。P1蛋白的哺乳动物组织交叉反应性通过P1的抗血清与正常兔组织，特别是心脏的切片的结合来证明。与未注射的对照组相比，注射P1蛋白的家兔心脏组织中单核白细胞数量也有统计学显著增加;变形菌Ingbritt没有产生这种效果。
A high molecular weight protein antigen, designated P1, has been isolated from the culture fluid of chemostat-grown Streptococcus mutans strain Ingbritt and shown to be free of other antigens including glucosyltransferase. Antiserum against the protein was used in rocket immunoelectrophoresis to confirm and extend the previous observation that there were major differences in the amount of the protein produced under different growth conditions. Physico-chemical and serological studies indicated that protein P1 was indistinguishable from antigens B, I/II and IF isolated in other laboratories. Mammalian tissue cross-reactivity of protein P1 was demonstrated by binding of antiserum to P1 to sections of normal rabbit tissues, particularly heart. There was also a statistically significant increase in the number of mononuclear leucocytes in heart tissue of rabbits which had been injected with protein P1, when compared with the levels in control uninjected rabbits; injection with whole cells of S. mutans Ingbritt did not produce this effect.
龋齿的免疫生物学：微生物方面和局部免疫。
影响因子：
10.5
作者：
McGhee,JR;Michalek,SM
通讯作者：
Michalek,SM