Glass microchip with three-dimensional microchannel network for 2 x 2 parallel synthesis
Glass microchip with three-dimensional microchannel network for 2 x 2 parallel synthesis
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DOI：
10.1039/b208382p
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发表时间：
2002-01-01
期刊：
影响因子：
6.1
通讯作者：
Kitamori, T
中科院分区：
文献类型：
--
作者：
Kikutani, Y;Horiuchi, T;Kitamori, T
在单片玻璃微芯片上开发了一个集成的2 - 3 - 2并行有机合成多反应器系统。芯片中的三维通道电路通过层叠三层玻璃板来制作。该制造方法是传统方法的简单扩展，可以轻松构建任何三维电路的拓扑等效性。2 3 2相转移酰胺形成反应构成了组合合成的简单模型，在微芯片上成功进行，并确认了三维电路的完整性。组合化学与多微反应器，结合高通量筛选方法的基础上mu-TAS技术，预计将提供一个有效的工具，药物发现。
An integrated multireactor system for 2 3 2 parallel organic synthesis has been developed on a single glass microchip. Three-dimensional channel circuits in the chip were fabricated by laminating three glass plate layers. The fabrication method is a straightforward extension of the conventional one, and topological equivalence for any three-dimensional circuits can be constructed easily with it. 2 3 2 phase-transfer amide formation reactions, which constitute a simple model for combinatorial synthesis, were successfully carried out on the microchip, and the integrity of the three-dimensional circuits was confirmed. Combinatorial chemistry with multi-microreactors, in conjunction with a high-throughput screening method based on mu-TAS technologies, is expected to provide an efficient tool for drug discovery.