Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress.
Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress.
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DOI：
10.1016/j.cmet.2015.06.022
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发表时间：
2015-08-04
期刊：
影响因子：
29
通讯作者：
Herndon DN
中科院分区：
文献类型：
--
作者：
Sidossis LS;Porter C;Saraf MK;Børsheim E;Radhakrishnan RS;Chao T;Ali A;Chondronikola M;Mlcak R;Finnerty CC;Hawkins HK;Toliver-Kinsky T;Herndon DN
由于棕色脂肪组织（BAT）的存在被证实在成年人，BAT已成为肥胖和胰岛素抵抗的治疗目标。我们研究了人类皮下白色脂肪组织（sWAT）是否可以采用BAT样表型使用长期和严重的肾上腺素能应激的临床模型。sWAT样本收集自严重烧伤和健康个体。一个子集的烧伤患者进行了前瞻性的后续急性住院治疗。sWAT的布朗宁由多室脂肪细胞、解偶联蛋白1（UCP 1）以及增加的线粒体密度和呼吸能力的存在确定。在烧伤患者的sWAT样本中发现了多房UCP1阳性脂肪细胞。烧伤后sWAT中UCP1 mRNA、线粒体密度和漏气量均增加。我们的数据表明，人类sWAT可以从能量储存组织转变为能量耗散组织，这为我们寻求预防和治疗肥胖及其代谢并发症开辟了新的研究途径。
Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We examined whether human subcutaneous white adipose tissue (sWAT) can adopt a BAT-like phenotype using a clinical model of prolonged and severe adrenergic stress. sWAT samples were collected from severely burned and healthy individuals. A subset of burn victims were prospectively followed during their acute hospitalization. Browning of sWAT was determined by the presence of multilocular adipocytes, uncoupling protein 1 (UCP1), and increased mitochondrial density and respiratory capacity. Multilocular UCP1-positive adipocytes were found in sWAT samples from burn patients. UCP1 mRNA, mitochondrial density and leak respiratory capacity in sWAT increased after burn trauma. Our data demonstrate that human sWAT can transform from an energy storing to energy dissipating tissue, which opens new research avenues in our quest to prevent and treat obesity and its metabolic complications.