THE EFFECTS OF ETHANOL ON EXPLORATION IN DBA/2 AND C57B1/6 MICE
THE EFFECTS OF ETHANOL ON EXPLORATION IN DBA/2 AND C57B1/6 MICE
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DOI：
10.1016/0741-8329(87)90054-1
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发表时间：
1987-01-01
期刊：
影响因子：
2.3
通讯作者：
LISTER, RG
中科院分区：
文献类型：
--
作者：
LISTER, RG
在洞板试验中评估了乙醇（0.8、1.6和2.4克/千克）对DBA/2和C57Bl/6小鼠行为的影响。乙醇导致C57Bl/6小鼠的运动活性呈剂量相关性下降，最高剂量还显著降低了探索性探头行为。相比之下，乙醇显著增加了DBA/2小鼠的运动活性。然而，只有最低剂量显著增加了探索性探头行为，最高剂量导致探索行为明显减少。这些结果强调了区分乙醇对运动和探索活动影响的重要性。
The effect of ethanol (0.8, 1.6, and 2.4 g/kg) was assessed on the behavior of DBA/2 and C57Bl/6 mice in a holeboard test. Ethanol caused a dose-related decrease in the locomotor activity of the C57Bl/mice, and the highest dose also significantly decreased exploratory head-dipping. In contrast ethanol significantly increased the locomotor activity of DBA/2 mice. Only the lowest dose, however, significantly increased exploratory head-dipping, and the highest dose caused a marked decrease in exploration. These results emphasize the importance of distinguishing between the effects of ethanol on locomotor and exploratory activities.