Endothelial function and common carotid artery wall thickening in patients with essential hypertension
Endothelial function and common carotid artery wall thickening in patients with essential hypertension
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DOI：
10.1161/01.hyp.32.1.25
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发表时间：
1998-07-01
期刊：
影响因子：
8.3
通讯作者：
Salvetti, A
中科院分区：
文献类型：
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作者：
Ghiadoni, L;Taddei, S;Salvetti, A
颈动脉壁的内膜-内侧增厚被认为是动脉粥样硬化的早期标志。与动脉粥样硬化发病机制有关的各种心血管危险因素的存在会损害内皮功能。为了评估血管反应性与颈动脉内膜内侧增厚之间的关系，我们在 44 名从未接受过治疗且血压升高史不超过 12 个月的原发性高血压患者（平均+/-SD 年龄，45.7+/-8.8 岁；范围，28 至 60 岁；31 名男性和 13 名女性）中评估了几个参数：颈总动脉的内膜内侧增厚（通过 B 模式）超声波）；前臂血管反应（通过应变计体积描记法）对臂内输注乙酰胆碱（每分钟 0.15、0.45、1.5、4.5 和 15 μg/100 mL 前臂组织）、内皮依赖性血管扩张剂或硝普钠（每分钟 1、2 和 4 μg/100 mL 前臂组织）、内皮依赖性血管扩张剂；计算最小前臂血管阻力（平均动脉压与13分钟缺血和1分钟运动引起的最大前臂血管舒张之间的比率）；和左心室质量指数（超声心动图）。颈动脉壁内膜内侧增厚显着（P
Intimal-medial thickening of the carotid wall is considered an early marker of atherosclerosis. Endothelial function is impaired in the presence of various cardiovascular risk factors that are implicated in the pathogenesis of atherosclerosis. To evaluate the relationship between vascular reactivity and carotid intimal-medial thickening, in 44 (mean+/-SD age, 45.7+/-8.8 years; range, 28 to 60 years; 31 men and 13 women) patients with essential hypertension who had never been treated and whose history of increased blood pressure was no longer than 12 months, we evaluated several parameters: intimal-medial thickening of the common carotid arteries (by B-mode ultrasound); forearm vascular response (by strain-gauge plethysmography) to intrabrachial infusion of acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 mu g/100 mL forearm tissue per minute), an endothelium-dependent vasodilator, or sodium nitroprusside (1, 2, and 4 mu g/100 mL forearm tissue per minute), an endothelium-independent vasodilator; calculated minimal forearm vascular resistances (the ratio between mean arterial pressure and maximal forearm vasodilation induced by 13 minutes of ischemia and 1 minute of exercise); and left ventricular mass index ton echocardiography profile). Carotid wall intimal-medial thickening showed a significant (P