Early events in the development of neuronal polarity in vitro are altered by ethanol
Early events in the development of neuronal polarity in vitro are altered by ethanol
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DOI：
10.1097/00000374-199809000-00013
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发表时间：
1998-09-01
影响因子：
3.2
通讯作者：
Lindsley, TA
中科院分区：
文献类型：
--
作者：
Clamp, PA;Lindsley, TA
产前暴露于乙醇的神经病理学影响之一是神经形态发生的破坏。乙醇对轴突和树突发育早期事件的影响进行了研究，使用培养的胚胎大鼠海马神经元，在体外开发的一个刻板的事件序列，模仿他们在体内的发展。在培养的第一个24小时，海马神经元附着在基底上，并发育成相差显微镜鉴定的三个阶段之一：（i）有板状伪足和无突起的神经元（阶段1）;（ii）发育小突起的神经元（阶段2）。
Among the neuropathological effects of prenatal exposure to ethanol is the disruption of neuromorphogenesis. The effects of ethanol on early events in the development of axons and dendrites were studied using cultured embryonic rat hippocampal neurons, which develop in vitro in a stereotypical sequence of events that mimics their development in vivo. During the first 24 hr in culture, hippocampal neurons attach to the substrate and develop into one of three stages identified by phase-contrast microscopy: (i) neurons having lamellipodia and no processes (stage 1); (ii) neurons developing minor processes (