AN X-RAY STUDY OF AZIDE METHAEMOGLOBIN
AN X-RAY STUDY OF AZIDE METHAEMOGLOBIN
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DOI：
10.1016/0022-2836(66)90088-x
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发表时间：
1966-01-01
影响因子：
5.6
通讯作者：
MATHEWS, FS
中科院分区：
文献类型：
--
作者：
PERUTZ, MF;MATHEWS, FS
酸性高铁血红蛋白和叠氮高铁血红蛋白之间的电子密度差异已通过 3 维 X 射线分析以 5.5 A 分辨率确定。在 a - 和 f) - 链中，唯一明显代表叠氮离子的显着峰位于铁原子和螺旋 E 之间，距铁原子仅超过 3 A 的距离，与肌球蛋白中的情况完全相同。叠氮化物离子深深地埋在血红素袋中，如果没有侧链摆动以允许它们进入，它们可能无法进入。
The difference in electron density between acid and azide methaemoglobin has been determined by X-ray analysis in 3 dimensions at 5.5 A resolution. In both the a - and f) -chains the only significant peaks, obviously representing the azide ions, lie between the iron atom and helix E, at a distance of just over 3 A from the iron atom, exactly as in myo-globin. The azide ions lie deeply buried in the haem pockets which they may not be able to enter without a side-chain swinging out of the way to allow them access.